Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
O M FarrC S Mantzoros

Abstract

There is some evidence that posttraumatic stress disorder (PTSD) and early life adversity may influence metabolic outcomes such as obesity, diabetes, and cardiovascular disease. However, whether and how these interact is not clear. We analyzed data from a cross-sectional and longitudinal study to determine how PTSD severity influences obesity, insulin sensitivity, and key measures and biomarkers of cardiovascular risk. We then looked at how PTSD and early life adversity may interact to impact these same outcomes. PTSD severity is associated with increasing risk of obesity, diabetes, and cardiovascular disease, with higher symptoms correlating with higher values of BMI, leptin, fibrinogen, and blood pressure, and lower values of insulin sensitivity. PTSD and early life adversity have an additive effect on these metabolic outcomes. The longitudinal study confirmed findings from the cross sectional study and showed that fat mass, leptin, CRP, sICAM-1, and sTNFRII were significantly increased with higher PTSD severity during a 2.5 year follow-up period. Individuals with early life adversity and PTSD are at high risk and should be monitored carefully for obesity, insulin resistance, and cardiometabolic risk.

References

Dec 1, 1995·Archives of General Psychiatry·R C KesslerC B Nelson
Mar 25, 2004·Current Psychiatry Reports·Alan M SteinbergRobert S Pynoos
Jul 27, 2006·Psychosomatic Medicine·Roland von KänelUlrich Schnyder
May 15, 2009·Journal of Clinical Psychopharmacology·Hua JinDilip V Jeste
Feb 23, 2010·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Eric A DedertJean C Beckham
May 21, 2010·Diabetes Care·Edward J BoykoUNKNOWN Millennium Cohort Study Team
Jan 23, 2013·Pediatrics·Sara B JohnsonJenna Riis
Feb 6, 2013·Brain, Behavior, and Immunity·Laura PlantingaViola Vaccarino
Feb 19, 2013·Journal of Traumatic Stress·Alan M SteinbergRobert S Pynoos
Feb 4, 2014·Clinical Psychology Review·Valerie A StanderRobyn M Highfill-McRoy
Mar 22, 2014·The Journal of Clinical Endocrinology and Metabolism·Kyoung Eun JoungChristos S Mantzoros

❮ Previous
Next ❯

Citations

Sep 26, 2015·Metabolism: Clinical and Experimental·Hao HuangLiegang Liu
Mar 1, 2016·Psychoneuroendocrinology·Sarah WilkerIris-Tatjana Kolassa
May 24, 2016·Journal of Psychosomatic Research·Carrie J NoblesLuana Marques
Jul 6, 2016·Experimental Neurology·Sarah N SchmeltzerRenu Sah
Jul 31, 2019·Journal of Women's Health·Jason D Flatt
Aug 8, 2020·Stress and Health : Journal of the International Society for the Investigation of Stress·Lotte van DammenTessa Roseboom
Aug 29, 2020·Nature Reviews. Gastroenterology & Hepatology·Arpana GuptaEmeran A Mayer
May 28, 2020·Journal of Endocrinological Investigation·H ZardoozF Khodagholi
Aug 30, 2018·Current Psychiatry Reports·Elizabeth Reisinger Walker, Benjamin G Druss
May 21, 2019·Frontiers in Human Neuroscience·Sung W Lee
Jul 23, 2020·Frontiers in Neuroscience·Julio D Vega-TorresJohnny D Figueroa
Mar 18, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carolina Muniz CarvalhoRenato Polimanti
Oct 4, 2017·Environmental Research·Leonardo TrasandeElaine M Urbina
Mar 9, 2021·Appetite·Francisco D MarquezAudrey R Tyrka
Apr 10, 2018·Biological Psychiatry·Synthia H MellonOwen M Wolkowitz
Nov 22, 2017·Brain, Behavior, and Immunity·Jennifer A SumnerLaura D Kubzansky
Apr 21, 2021·The European Journal of Neuroscience·Ellen DoneyCaroline Menard
Dec 3, 2020·Journal of Psychiatric Research·Taona P HaderleinDonna L Washington

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Antipsychotic-Induced Weight Gain

Antipsychotic-induced weight gain (aiwg) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. Here are the latest discoveries pertaining to AIWG.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine
Eric A DedertJean C Beckham
American Journal of Preventive Medicine
Axel PerkoniggHans-Ulrich Wittchen
JAAPA : Official Journal of the American Academy of Physician Assistants
Louis J Aronne
© 2021 Meta ULC. All rights reserved