Posttraumatic stress disorder is associated with enhanced interleukin-6 response to mental stress in subjects with a recent myocardial infarction

Brain, Behavior, and Immunity
Bruno B LimaViola Vaccarino

Abstract

Posttraumatic Stress Disorder (PTSD) is prevalent among patients who survived an acute coronary syndrome, and is associated with adverse outcomes, but the mechanisms underlying these associations are unclear. Individuals with PTSD have enhanced sensitivity of the noradrenergic system to stress which may lead to immune activation. We hypothesized that survivors of a myocardial infarction (MI) who have PTSD would show an enhanced inflammatory response to acute psychological stress compared to those without PTSD. Individuals with a verified history of MI within 8 months and a clinical diagnosis of current PTSD underwent a mental stress speech task. Inflammatory biomarkers including interleukin-6 (IL-6), high-sensitivity C reactive protein (HsCRP), matrix metallopeptidase 9 (MMP-9), intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and monocyte chemoattractant protein (MCP)-1 were measured at rest and 90 min after mental stress. Among 271 patients in the study (mean age 51 ± 7 years, 50% female, 60% African-American), the prevalence of PTSD was 12%. Mental stress resulted in a significant increase in IL-6, but the increase was more marked in patients with PTSD (126% increase) than those without (63%...Continue Reading

References

Feb 1, 1983·The American Journal of Cardiology·G G Gensini
Aug 1, 1996·Behaviour Research and Therapy·E B BlanchardC A Forneris
May 1, 1997·The American Journal of Psychiatry·J D BremnerD S Charney
Oct 17, 2001·The Journal of Clinical Investigation·M VenihakiK P Karalis
Jan 11, 2002·The New England Journal of Medicine·Rachel Yehuda
Dec 20, 2002·Nature·Peter Libby
Feb 6, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Chin K KimDavid S Sheps
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Angelika BierhausPeter P Nawroth
May 3, 2005·The American Journal of Psychiatry·Dewleen G BakerThomas D Geracioti
Mar 7, 2006·Journal of the American College of Cardiology·Srikanth RamachandruniDavid S Sheps
Nov 27, 2007·Journal of the American College of Cardiology·Kristian ThygesenUNKNOWN Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction
Nov 27, 2007·Progress in Brain Research·C S de KloetH G M Westenberg
May 30, 2009·Journal of cardiology·Epaminondas Zakynthinos, Nikolitsa Pappa
Oct 12, 2010·Brain, Behavior, and Immunity·Thaddeus W W Pace, Christine M Heim
Jun 30, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Alicia K SmithKerry J Ressler
Jul 25, 2012·Annals of the New York Academy of Sciences·Nicolas RohlederMatthias Boentert
Nov 7, 2012·Neuroscience and Biobehavioral Reviews·Aoife O'DonovanThomas C Neylan
Feb 6, 2013·Brain, Behavior, and Immunity·Laura PlantingaViola Vaccarino
Mar 5, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Anna C PhillipsBrian M Hughes
Jul 3, 2013·Journal of the American College of Cardiology·Viola VaccarinoJ Douglas Bremner
Aug 3, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ayman A HusseinDonald Lloyd-Jones
Nov 2, 2013·American Heart Journal·Donald EdmondsonMatthew M Burg
May 28, 2014·European Heart Journal·Paul M Ridker, Thomas F Lüscher
Jan 4, 2015·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Matthew H BeristianosAmy L Byers
Nov 7, 2015·The Lancet. Psychiatry·Ives Cavalcante PassosMárcia Kauer-Sant'Anna
Mar 5, 2016·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Romano EndrighiAndrew Steptoe
Aug 9, 2016·Neuroscience and Biobehavioral Reviews·Viola Vaccarino, J Douglas Bremner
Aug 31, 2016·Evidence-based Mental Health·Aoife O'Donovan
Jan 23, 2017·The Lancet. Psychiatry·Donald Edmondson, Roland von Känel
Jun 3, 2017·International Journal of Cardiology·Muhammad HammadahArshed A Quyyumi

❮ Previous
Next ❯

Citations

May 6, 2019·European Heart Journal Cardiovascular Imaging·Puja K MehtaC Noel Bairey Merz
Jun 5, 2019·Stress : the International Journal on the Biology of Stress·Marlene A WilsonFrancis G Spinale
Sep 4, 2019·Journal of Clinical Psychology in Medical Settings·Jonathan Jun Liang TanBiing-Jiun Shen
Feb 25, 2020·The Journal of Nervous and Mental Disease·J Douglas BremnerViola Vaccarino
Oct 3, 2020·Journal of Traumatic Stress·Murielle Jacquet-SmailovicMarie-Jo Brennstuhl
Sep 13, 2020·Journal of Personalized Medicine·James Douglas BremnerOmer T Inan
Aug 23, 2020·Nutrients·J Douglas BremnerViola Vaccarino
Feb 15, 2021·General Hospital Psychiatry·Samuel CyrJudith Brouillette
Dec 29, 2020·Frontiers in Neuroscience·Catherine GebhardMichael Fiechter
Dec 11, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ronald J EllisRobert K Heaton
May 23, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Céleste M ChevalierUlrike Schmidt
Aug 28, 2021·International Journal of Molecular Sciences·Francisco J Carrera AriasTravis J A Craddock

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.