Posttreatment high-grade glioma: usefulness of peak height position with semiquantitative MR perfusion histogram analysis in an entire contrast-enhanced lesion for predicting volume fraction of recurrence

Radiology
Ho Sung KimSun Yong Kim

Abstract

To determine whether semiquantitative histogram analysis of the normalized cerebral blood volume (CBV) for an entire contrast material-enhanced lesion could be used to predict the volume fraction of posttreatment high-grade glioma recurrence compared with posttreatment change. The institutional review board approved this retrospective study. Informed consent was obtained. Thirty-nine patients with pathologically proved predominant tumor recurrence (tumor recurrence group, tumor fraction > or =50% [n = 14]), mixed tumor and posttreatment change (mixed group, tumor fraction > or =20% and <50% [n = 10]), and predominant posttreatment change (treatment change group, tumor fraction <20% [n = 15]) were evaluated. Histogram parameters of normalized CBV-histogram width, peak height position (PHP), and maximum value (MV)-were measured in entire contrast-enhanced lesions and used as discriminative indexes. Ordered logistic regression was used to determine independent factors for predicting the diseases of posttreatment contrast-enhanced lesions. Leave-one-out cross-validation was used to determine diagnostic accuracy. PHP was an independent predictive factor (P = .003) for differentiating contrast-enhanced lesions in patients with posttr...Continue Reading

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Citations

Dec 14, 2011·Neuroradiology·Katrin HaeglerJennifer Linn
Jan 23, 2016·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Wooyul PaikSang Joon Kim
May 3, 2012·Neuroimaging Clinics of North America·Seung-Koo Lee
Nov 21, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Norbert GalldiksKarl-Josef Langen
Nov 10, 2018·The British Journal of Radiology·Derek R JohnsonTimothy J Kaufmann
Mar 24, 2012·The American Journal of Surgical Pathology·Jang-Hee KimKyi Beom Lee
May 4, 2018·Journal of Neuro-oncology·Andrea RomanoAlessandro Bozzao
Jul 10, 2019·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Crystal FongJeffrey Greenspoon
Sep 1, 2015·Neuro-oncology Practice·Derek R JohnsonJennifer L Clarke

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