Posttreatment reactivation of tuberculosis in mice caused by Mycobacterium tuberculosis disrupted in mce1R.

The Journal of Infectious Diseases
Chan-Ick CheighLee W Riley

Abstract

The reactivation of tuberculosis arises in persons who are latently infected and in those who have been previously treated. The mechanism of the reactivation of tuberculosis in either situation is not well understood. A 13-gene mce1 operon of Mycobacterium tuberculosis was previously shown to be associated with latent infection in mice and may also play a role in reactivation. We tested mce1 operon M. tuberculosis mutants in a Cornell mouse model to examine disease progression and reactivation. In BALB/c mice, the wild-type, mce1 operon mutant, and mce1R (negative transcriptional regulator of the mce1 operon) mutant M. tuberculosis strains were equally susceptible to orally administered isoniazid and pyrazinamide. However, after cessation of the treatment, the mce1R mutant rapidly and progressively proliferated in mouse lungs and spleens, whereas the other strains remained latent. The reactivation of the mce1R mutant was associated with disease progression in the mouse lungs. This observation demonstrates that the constitutive expression of the mce1 genes by M. tuberculosis in the latent state can cause a reactivation of tuberculosis. The constitutive expression of the mce1 genes in the mce1R mutant may allow this mutant to mai...Continue Reading

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Citations

Aug 6, 2013·The Clinical Respiratory Journal·Amador GoodridgeLee W Riley
Oct 19, 2012·Virulence·Marina A ForrelladFabiana Bigi
Apr 26, 2011·Vaccine·Andrés Obregón-HenaoFabiana Bigi
Jul 8, 2016·International Journal of Experimental Pathology·Shahnawaz MajeedSadhna Sharma
May 7, 2020·Frontiers in Cellular and Infection Microbiology·Matthew B HuanteJanice J Endsley
Jan 25, 2011·Molecular and Cellular Biochemistry·Fan Zhang, Jian-Ping Xie
Sep 16, 2017·Trends in Microbiology·Ashley V Veatch, Deepak Kaushal

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