Postural control during galvanic vestibular stimulation in patients with persistent perceptual-postural dizziness

Journal of Neurology
Josephin WollChristoph Helmchen

Abstract

Over the past years galvanic vestibular stimulation (GVS) has been increasingly applied to stimulate the vestibular system in health and disease, but not in patients with persistent postural-perceptual dizziness (PPPD) yet. We functionally tested motion perception thresholds and postural responses to imperceptible noisy (nGVS) and perceptible bimastoidal GVS intensities in patients with PPPD with normal vestibulo-ocular reflexes. We hypothesized that GVS destabilizes PPPD patients under simple postural conditions stronger compared to healthy controls. They were compared to healthy subjects under several conditions each with the eyes open and closed: baseline with firm platform support, standing on foam and cognitive demand (count backward). Low and high GVS intensities (range 0.8-2.8 mA) were applied according to the individual thresholds and compared with no GVS. PPPD patients showed a reduced perception threshold to GVS compared to healthy control subjects. Median postural sway speed increased with stimulus intensity and on eye closure, but there was no group difference, irrespective of the experimental condition. Romberg's ratio was consistently lower during nGVS than in all other conditions. Group-related dissociable effect...Continue Reading

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Citations

Nov 28, 2020·Frontiers in Neurology·Viviana MucciBruno Burlando
Jun 22, 2021·Journal of Vestibular Research : Equilibrium & Orientation·Georgina PowellPetroc Sumner
Aug 12, 2021·International Archives of Otorhinolaryngology·Eliane Maria Dias von Söhsten LinsJeffrey Paul Staab

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