PMID: 9191877May 1, 1997Paper

Postural effects on peritoneal transport and systemic uptake of radiolabeled monoclonal antibodies

Cancer Immunology, Immunotherapy : CII
J S BarrettR L Wahl

Abstract

To optimize the regional delivery advantage with i.p. administration of monoclonal antibody (mAb) for radioimmunotherapy, it may be possible to delay the rate and extent of mAb absorption from the peritoneal cavity by simply altering the position of a patient after radioantibody administration. It has been shown that the hydrostatic pressure against the diaphragm plays a major role in the rate of egress of radioantibodies from the peritoneal cavity and that fluid removal from the peritoneal cavity can be altered by posture. The current study examined postural effects in normal rats following the i.p. injection of 125I-5G6.4 murine IgG2a anticarcinoma antibody (45 microCi). A 10-ml injection volume of the radioantibody solution was administered to rats restrained in either a supine or inclined (reverse Trendelenburg; feet down at a 45 degrees angle) position. Pharmacokinetic analysis confirmed that the appearance of the radioantibody into the systemic circulation was delayed in the inclined group. The time to peak blood concentration was prolonged from 14.7 (supine) to 19.2 (inclined) hours (P = 0.005). All other pharmacokinetic parameters were equivalent across the treatment groups. The mean half-life of 166 h, mean blood clear...Continue Reading

Citations

Aug 25, 2012·Regulatory Toxicology and Pharmacology : RTP·Tomasz GrabowskiMonica Whitmire
Dec 19, 2000·Artificial Organs·K CzyzewskaJ Waniewski

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