Postural hand tremor before and following liver transplantation and immunosuppression with cyclosporine or tacrolimus in patients without clinical signs of hepatic encephalopathy

Clinical Transplantation
Friedemann PaulJörg Wissel

Abstract

To assess tremor characteristics and severity in patients with severe liver disease without hepatic encephalopathy and following orthotopic liver transplantation (LTX) and immunosuppression (IS) with cyclosporin A (CsA) or tacrolimus (FK 506). A total of 35 consecutive patients were included into the prospective study and serum levels of CsA (n = 29) or FK 506 (n = 6) were monitored following LTX. Tremor characteristics and severity were assessed by two-blinded raters before and following LTX. In addition, accelerometric recordings were taken before and after LTX, and compared with 16 normal controls without tremor and without clinical signs of hepatic encephalopathy or liver disease. Accelerometry was performed while sitting in a comfortable chair with the forearms supported and included rest and postural condition with and without weight load (500 g) on each hand. Kolmogorov-Smirnov test, paired t-test and t-test for independent samples were used for statistical analysis. The clinical rating revealed no rest but a mild postural hand tremor before LTX with a significant increase following LTX (p < 0.001). After LTX the mean score of postural tremor was significantly (p < 0.05) higher in patients with plasma levels of >850 ng C...Continue Reading

References

Jun 1, 1992·Annals of Neurology·D P SteinT A Broughan
Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O L LopezD H van Thiel
Jul 1, 1991·Annals of Neurology·Z K WszolekP C de Groen
Dec 21, 1989·The New England Journal of Medicine·B D Kahan
Jun 1, 1988·Transplantation·D P VogtT A Broughan
Apr 25, 1987·Lancet·D H AdamsP McMaster
Oct 3, 1985·The New England Journal of Medicine·C L Fraser, A I Arieff
May 1, 1988·Neurologic Clinics·A J MartinezA A Faris
Oct 1, 1987·The New England Journal of Medicine·P C de GroenR A Krom
May 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·V HömbergH J Freund
Feb 1, 1986·Neurology·R J Elble
Aug 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·P Bain
Aug 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·P G BainC D Marsden
Jan 1, 1993·Acta Neurologica Scandinavica·E MorenoF Perez-Cerda
Jun 5, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·M S LeDouxK Sethi
Jul 10, 1999·Journal of Neurology·J M GijtenbeekC J Vecht
Oct 29, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·W O Bechstein
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·P NeuhausC Groth
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·K TrochaC Ehrenheim
Mar 13, 2002·Lancet·Raimund Margreiter, UNKNOWN European Tacrolimus vs Ciclosporin Microemulsion Renal Transplantation Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Miguel-Angel Guillen-Anaya, Michel Jadoul
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Olaf HeiselPaul Keown
© 2022 Meta ULC. All rights reserved