Postural orthostatic tachycardia syndrome and the potential role of mast cell activation

Autonomic Neuroscience : Basic & Clinical
Taylor A Doherty, Andrew A White

Abstract

Though a sizeable amount of data connects mast cell activity to the neurologic system, less is known about the true clinical implications of this relationship. Even less is understood about treatment strategies in those with both allergic and neurologic complaints. This is particularly true in postural orthostatic tachycardia syndrome (POTS), a common type of dysautonomia, where patients are burdened by symptoms of orthostatic cerebral hypoperfusion and several other comorbidities that are likely influenced by autonomic tone. Some patients describe characteristic allergic symptoms, in the absence of typical IgE mediated triggers, and also improvement with traditional mast cell directed medications. Further work is necessary to determine whether these anecdotal observations are valid. The answer to this question will likely be addressed as the mechanisms of POTS are better characterized, which may include a phenotype with distinct mast cell involvement.

Citations

Aug 15, 2019·Annual Review of Medicine·Philip L Mar, Satish R Raj
Jan 30, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Leonard B WeinstockGerhard J Molderings
Feb 11, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Mitchell G MiglisLynn Marie Trotti
Apr 25, 2020·Digestive Diseases and Sciences·Leonard B WeinstockGerhard J Molderings
Nov 4, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yixi TuPhilip L Mar
Dec 2, 2020·Clinical and Translational Gastroenterology·Florencia CarboneJan Tack
Dec 22, 2020·Autonomic Neuroscience : Basic & Clinical·Alice LoughnanStephen James

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