Postural tremor in Wilson's disease: a magnetoencephalographic study

Movement Disorders : Official Journal of the Movement Disorder Society
Martin SüdmeyerAlfons Schnitzler

Abstract

The following study included 5 Wilson's disease (WD) patients showing a right-sided postural forearm tremor (4-6 Hz) and addressed the question of whether the primary motor cortex (M1) is involved in tremor generation. Using a 122-channel whole-head neuromagnetometer and surface electromyogram (EMG), we investigated cerebromuscular coupling. Postural tremor was observed in a sustained 45-degree posture of the right-sided forearm. Data were analyzed using dynamic imaging of coherent sources (DICS), revealing cerebromuscular coupling between EMG and cerebral activity. Coherent sources were superimposed on individual high-resolution T1-weighted magnetic resonance images (MRI). Phase lags between EMG and cerebral areas showing strongest coherence were determined by means of a Hilbert transform of both signals. In all patients, postural tremor was associated with strong coherence between tremor EMG and activity in contralateral primary sensorimotor cortex (S1/M1) at tremor or double tremor frequency. Phase lag values between S1/M1 activity and EMG revealed efferent and afferent components in the corticomuscular coupling. Taken together, our results indicate that postural tremor in WD is mediated through a pathological oscillatory dr...Continue Reading

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Citations

Sep 26, 2013·Journal of the Neurological Sciences·Ketaki S BhalsingPramod Kr Pal
Dec 7, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·L TimmermannA Schnitzler
Jan 31, 2006·International Review of Neurobiology·Alfons Schnitzler, Joachim Gross
Sep 23, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Martin SüdmeyerAlfons Schnitzler
Oct 18, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Martin SüdmeyerAlfons Schnitzler
Apr 2, 2005·Nature Reviews. Neuroscience·Alfons Schnitzler, Joachim Gross
Jun 11, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Alfons SchnitzlerJoachim Gross

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