PMID: 6407036May 1, 1983Paper

Posture-independent sensorimotor analysis of inter-hemispheric receptor asymmetries in neostriatum

Pharmacology, Biochemistry, and Behavior
T SchallertD M Vaughn

Abstract

Nigrostriatal dopaminergic neurons are thought to be critically important for somato-sensorimotor behavior. Following unilateral irreversible elimination of these neurons, an animal shows an ipsiversive postural bias and permanently fails to orient its head toward tactile stimuli placed on the contralateral side of the body. In response to apomorphine, a dopamine agonist, these rats display contraversive circling. This effect is thought to reflect denervation-induced proliferation of dopamine receptors in the ipsilateral striatum. We have developed a sensitive procedure that measures sensorimotor function independent of postural and circling biases. We record the latencies to remove small pieces of adhesive stimuli placed onto the snout or radial surface of the forelimbs. The stimuli are placed symmetrically and simultaneously, which is analogous to tactile-extinction procedures used clinically. In the first study we found that rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the nigrostriatal pathway showed a contralateral sensorimotor bias in response to doses of apomorphine below those necessary to produce contraversive circling. In a second study, unilateral striatal microinjections of kainic acid (KA) wer...Continue Reading

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Citations

Aug 14, 2012·Psychopharmacology·George T TaylorBrenda A Kirchhoff
Dec 1, 1992·Journal of the Neurological Sciences·S HallT Schallert
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·L A Parker, N Lopez
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·K LeebR Eikelboom
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Timothy Schallert
Apr 7, 2005·Physiology & Behavior·Eddie CastañedaMichal K Stachowiak
Jul 9, 2002·Journal of Neuroscience Methods·Li ZhangMichael Chopp
Aug 31, 2006·Behavioural Pharmacology·Sheila M Fleming, Marie-Françoise Chesselet
Mar 3, 2006·Journal of Neurosurgery·Ya HuaGuohua Xi
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Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Axel LeingärtnerDennis D M O'Leary
Apr 23, 2009·Journal of Neuroscience Methods·Kelly A Tennant, Theresa A Jones
Jul 6, 2010·Journal of Neuroscience Methods·Virginie Beray-BerthatIsabelle Margaill
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Nov 15, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Thomas FreretOmar Touzani
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