Potassium and insulin affect the contractility of abomasal smooth muscle

Journal of Dairy Science
G Türck, S Leonhard-Marek

Abstract

Abomasal displacement is a frequent and important disease of high yielding dairy cows. Although several factors are related to its occurrence, the pathogenesis of the condition is still inadequately understood, particularly in regard to K(+) and insulin homeostasis. For this reason the aim was to investigate the effects of K(+) and insulin concentrations on in vitro motility of abomasal smooth muscle. The second aim was to determine whether the in vivo change in K(+) and insulin levels might be sufficient to induce reduced abomasal motility. Muscle strips were isolated from the abomasum of slaughtered cows and incubated in buffer solution under isometric conditions. Results show that a decrease in extracellular K(+) (between 5 and 1 mmol/L) or an increase in extracellular insulin concentrations (to 21 mU/L or higher) were able to affect the contraction activity of abomasal muscles. Contraction activity given as median (25th, 75th percentiles) changed from 28.1 mN/min (2.5, 49.9) at 5 mmol/L of K(+) to 9.4 mN/min (0.6, 35.7) at 1 mmol/L of K(+), and from 34.5 mN/min (10.8, 112.4) at 0 mU/L of insulin to 12.0 mN/min (7.6, 49.8) at 120 mU/L of insulin. Because the effect of insulin could be abolished by barium, glybenclamide, or o...Continue Reading

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Citations

Mar 1, 2013·Journal of the American Veterinary Medical Association·Peter ConstableHenry R Stämpfli
Mar 1, 2012·The Veterinary Clinics of North America. Food Animal Practice·Peter D ConstableThomas Wittek
Oct 11, 2017·Journal of Dairy Science·M BergS Röblitz
Dec 23, 2017·Asian Pacific Journal of Tropical Medicine·Hafiz Muhammad Abdur RahmanImran Imran

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