Potassium and sodium microdomains in thin astroglial processes: A computational model study

PLoS Computational Biology
Kevin BreslinLiam McDaid

Abstract

A biophysical model that captures molecular homeostatic control of ions at the perisynaptic cradle (PsC) is of fundamental importance for understanding the interplay between astroglial and neuronal compartments. In this paper, we develop a multi-compartmental mathematical model which proposes a novel mechanism whereby the flow of cations in thin processes is restricted due to negatively charged membrane lipids which result in the formation of deep potential wells near the dipole heads. These wells restrict the flow of cations to "hopping" between adjacent wells as they transverse the process, and this surface retention of cations will be shown to give rise to the formation of potassium (K+) and sodium (Na+) microdomains at the PsC. We further propose that a K+ microdomain formed at the PsC, provides the driving force for the return of K+ to the extracellular space for uptake by the neurone, thereby preventing K+ undershoot. A slow decay of Na+ was also observed in our simulation after a period of glutamate stimulation which is in strong agreement with experimental observations. The pathological implications of microdomain formation during neuronal excitation are also discussed.

References

Nov 1, 1979·Physics in Medicine and Biology·K R FosterH P Schwan
Apr 1, 1967·The Journal of Physiology·R Elul
Jun 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W Walz, L Hertz
Sep 1, 1993·Neuron·D AttwellM Szatkowski
Nov 9, 2002·Science·Bruce Alberts, Robert M May
Nov 25, 2004·Neuroscience·P Kofuji, E A Newman
Mar 28, 2006·Journal of Cellular and Molecular Medicine·Arthur M Butt, Amanpreet Kalsi
May 19, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anke WallraffChristian Steinhäuser
Jan 19, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Alexei Verkhratsky, Frank Kirchhoff
Feb 3, 2007·Pflügers Archiv : European journal of physiology·Sergei KirischukAlexei Verkhratsky
Dec 6, 2008·Science·Nathalie RouachChristian Giaume
Sep 19, 2009·Cell Death and Differentiation·D BoisonB B Fredholm
Sep 29, 2009·Critical Reviews in Biochemistry and Molecular Biology·Bengt Fadeel, Ding Xue
Oct 28, 2009·The Journal of Physiology·Julia Langer, Christine R Rose
Jan 21, 2010·Nature Reviews. Neuroscience·Christian GiaumeNathalie Rouach
Jul 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Markus ReicholdRichard Warth
Apr 30, 2011·Physiological Reviews·Helmut KettenmannAlexei Verkhratsky
Jun 21, 2011·Nature Reviews. Neuroscience·Claire RibraultAntoine Triller
Jan 10, 2012·Glia·Maiken Nedergaard, Alexei Verkhratsky
May 29, 2012·Trends in Neurosciences·Sergei KirischukAlexei Verkhratsky
Dec 18, 2012·Translational Neuroscience·Vladimir Parpura, Alexei Verkhratsky
Oct 19, 2013·Physiological Reviews·Robert J Vandenberg, Renae M Ryan
Nov 12, 2013·Biophysical Journal·Alexandra WitthoftGeorge Em Karniadakis
Nov 19, 2013·Pflügers Archiv : European journal of physiology·Christof GrewerThomas Rauen
Nov 26, 2013·Frontiers in Endocrinology·Yun Zhou, Niels Christian Danbolt
Dec 25, 2013·PLoS Computational Biology·Geir HalnesGaute T Einevoll
Sep 17, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alexei Verkhratsky, Maiken Nedergaard
Sep 23, 2014·Advances in Neurobiology·Arne SchousboeMary C McKenna
Feb 27, 2016·Glia·Christine R Rose, Alexei Verkhratsky
Jul 6, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alexei Verkhratsky, Maiken Nedergaard

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Citations

Feb 9, 2019·The Journal of Physiology·Alexei VerkhratskyChristine R Rose
Aug 10, 2019·Frontiers in Cellular Neuroscience·Junxiu LiuDavid M Halliday
Sep 27, 2020·Pflügers Archiv : European journal of physiology·Alexei VerkhratskyAlexey Semyanov
May 28, 2019·Frontiers in Cellular Neuroscience·John Joseph WadeLiam McDaid
Sep 10, 2020·Frontiers in Physiology·Lisa FelixChristine R Rose
Aug 10, 2020·Neuroscience and Biobehavioral Reviews·Marcus Augusto-OliveiraMaria Elena Crespo-Lopez
Mar 19, 2021·Frontiers in Cellular Neuroscience·László HéjaJulianna Kardos
May 29, 2020·Neuropharmacology·Matjaž StenovecRobert Zorec
Jun 19, 2021·PLoS Computational Biology·Manu KaliaChristine R Rose

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