PMID: 6237811Jul 1, 1984Paper

Potassium and the heart

Clinics in Endocrinology and Metabolism
P A Poole-Wilson


The electrical stability of the heart is more sensitive to the extracellular than to the intracellular potassium concentration. During exercise, extracellular potassium varies rapidly. Catecholamines also modulate the plasma potassium concentration. Hypokalaemia of any cause can precipitate arrhythmias. Ischaemic myocardium loses potassium into the extracellular space within seconds and the cell becomes depolarized. The rise of the extracellular potassium ion concentration accounts for many of the early electrophysiological changes. Abrupt changes of plasma potassium concentration in normal myocardium and a high potassium concentration in ischaemic myocardium can set up electrical forces which initiate arrhythmias. The same phenomenon can account for changes on the electrocardiogram early after the cessation of an exercise test in a patient with ischaemic heart disease. Accumulation of potassium between cells in response to an increase of heart rate is a possible mechanism for false positive exercise tests and Syndrome X.


Aug 19, 1978·Lancet·E CarlssonL Svensson
Dec 1, 1978·Clinical Science and Molecular Medicine. Supplement·P A Poole-WilsonC H Fry
Jul 1, 1979·The Journal of Clinical Investigation·G L ConradK I Shine
Aug 11, 1979·British Medical Journal·J LoweD H Lawson
Feb 19, 1977·British Medical Journal
Apr 16, 1977·British Medical Journal·R Krakauer
Aug 19, 1976·Nature·I CohenD Noble
Apr 1, 1975·American Heart Journal·R H SellerC Swartz
Jun 1, 1975·The Journal of General Physiology·C O Lee, H A Fozzard
May 22, 1976·British Medical Journal·E K DonaldsonG A Alleyne
Jul 1, 1973·Canadian Journal of Physiology and Pharmacology·V BalasubramanianN S Dhalla
Nov 8, 1973·The New England Journal of Medicine·T W Smith, E Haber
Nov 9, 1974·British Medical Journal
Dec 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·M KusumotoR Boucher
Nov 15, 1973·The New England Journal of Medicine·T W Smith, E Haber
Nov 1, 1973·The New England Journal of Medicine·T W Smith, E Haber
Nov 22, 1973·The New England Journal of Medicine·T W Smith, E Haber
Sep 12, 1981·Lancet·M LimD M Band
Dec 5, 1981·Lancet·L CoreaP Verdecchia
Sep 1, 1980·Cardiovascular Research·D Noble
Aug 1, 1983·British Heart Journal·S C WebbP A Poole-Wilson
Dec 8, 1983·The New England Journal of Medicine·M J BrownM B Murphy
Oct 1, 1983·Journal of Molecular and Cellular Cardiology·G A Langer
Dec 1, 1983·British Heart Journal·J E Nordrehaug, G von der Lippe

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