Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets

Stroke; a Journal of Cerebral Circulation
R VeltkampDavid W Busija

Abstract

Cerebral arteriolar dilation to N-methyl-D-aspartate (NMDA) is a neuronally mediated multistep process that is sensitive to cerebral hypoxia and ischemia (H/I). We tested the hypothesis that topical pretreatment with the selective potassium channel agonists NS1619 and aprikalim preserves the vascular response to NMDA after consecutive H/I. Pial arteriolar diameters were measured in anesthetized piglets with the use of a closed cranial window and intravital microscopy. Arteriolar responses to NMDA (10(-5), 5 x 10(-5), and 10(-4) mol/L) were recorded before and 1 hour after 10 minutes of hypoxia (8.5% O2 in N2) plus 10 minutes of ischemia (H/I). Ischemia was induced by increasing intracranial pressure. Subgroups were topically pretreated with 10(-5) mol/L NS1619, 10(-6) mol/L aprikalim, 10(-6) mol/L calcitonin gene-related peptide (CGRP), or 10(-5) mol/L papaverine. We also examined the effects of H/I on vascular responses to kainate (10(-4) mol/L) to assess specificity of neuronal injury. Arteriolar responses to NMDA were significantly attenuated after H/I. Baseline compared with post-H/I arteriolar diameters were 9+/-4% versus 3+/-2% at 10(-5) mol/L, 22+/-4% versus 4+/-2% at 5 x 10(-5) mol/L, and 33+/-4% versus 7+/-2% at 10(-4)...Continue Reading

References

Dec 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P M BeartD T Manallack
Oct 1, 1988·The American Journal of Physiology·W G MayhanD D Heistad
Dec 1, 1994·British Journal of Pharmacology·G EdwardsA H Weston
Apr 1, 1995·The American Journal of Physiology·M T Nelson, J M Quayle
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·C HeurteauxM Lazdunski
Jun 1, 1994·Cardiovascular Research·U QuastI Cavero
Jan 1, 1994·Progress in Brain Research·D W Choi
Jan 4, 1994·European Journal of Pharmacology·S P OlesenJ Drejer
Feb 14, 1994·Neuroscience Letters·D J HoffmanM Delivoria-Papadopoulos
Jul 1, 1993·The American Journal of Physiology·D W Busija, M Wei
Jan 1, 1996·Life Sciences·T Kristián, B K Siesjö
Jan 1, 1996·Pharmacology & Therapeutics·K Lawson
Apr 1, 1996·The American Journal of Physiology·D W BusijaT M Louis
Dec 1, 1996·Clinical and Experimental Pharmacology & Physiology·F M Faraci, C G Sobey
Mar 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M W RiepeJ Hugon
Jan 1, 1997·Advances in Pharmacology·M L GarciaG J Kaczorowski
Dec 9, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F BariD W Busija

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Citations

Jun 1, 2004·Brain Research Bulletin·Gao JingJames Weyhenmeyer
May 5, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·John H ZhangAustin Colohan
Jun 15, 2005·Journal of Molecular and Cellular Cardiology·A Jahangir, Andre Terzic
Feb 5, 2002·Expert Opinion on Pharmacotherapy·A JahangirW K Shen
Jun 16, 2009·Brain Research·Tamás GáspárDavid W Busija
Dec 2, 2004·Brain Research. Brain Research Reviews·David W BusijaTakashi Horiguchi
Sep 1, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hong XieLie-Ju Liu
Aug 11, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·V K GribkoffS I Dworetzky
Aug 2, 2000·Arquivos de neuro-psiquiatria·R J Gagliardi
Nov 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James V PerciaccanteDavid W Busija
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·W M Armstead
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Katsuyoshi ShimizuDavid W Busija
Feb 23, 2019·Frontiers in Neuroscience·Parto S Khansari, Robert F Halliwell

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