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Potassium channel dysfunction in human neuronal models of Angelman syndrome

Science

Dec 21, 2019

Alfred Xuyang SunHyunsoo Shawn Je

Abstract

Disruptions in the ubiquitin protein ligase E3A (UBE3A) gene cause Angelman syndrome (AS). Whereas AS model mice have associated synaptic dysfunction and altered plasticity with abnormal behavior, whether similar or other mechanisms contribute to network hyperactivity and epilepsy susce...read more

Mentioned in this Paper

Finding
Potassium Channel
Ubiquitinated Protein Degradation
Neurons
Hyperactive Behavior
Antagonists
Seizures
Neoplasms, Multiple Primary
Calcium Channel
Calcium-Activated Potassium Channel Subunit Alpha-1
65
4
2
1
2
Paper Details
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The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

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Potassium channel dysfunction in human neuronal models of Angelman syndrome

Science

Dec 21, 2019

Alfred Xuyang SunHyunsoo Shawn Je

PMID: 31857479

DOI: 10.1126/science.aav5386

Abstract

Disruptions in the ubiquitin protein ligase E3A (UBE3A) gene cause Angelman syndrome (AS). Whereas AS model mice have associated synaptic dysfunction and altered plasticity with abnormal behavior, whether similar or other mechanisms contribute to network hyperactivity and epilepsy susce...read more

Mentioned in this Paper

Finding
Potassium Channel
Ubiquitinated Protein Degradation
Neurons
Hyperactive Behavior
Antagonists
Seizures
Neoplasms, Multiple Primary
Calcium Channel
Calcium-Activated Potassium Channel Subunit Alpha-1
65
4
2
1
2

Similar Papers Found In These Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

General Biology Journal eTOCs

Discover the latest general biology research in this collection of the top biology journals.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice

The Journal of Neuroscience : the Official Journal of the Society for NeuroscienceDecember 15, 2015
Emanuela SantiniHanoch Kaphzan
Paper Details
References
  • References46
  • Citations
12345
  • References46
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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