Potassium channels in neuropathic pain: advances, challenges, and emerging ideas

Pain
Jérôme BusserollesJosé A López García

Abstract

A workshop of the 2015 International Neuropathic Pain Congress was focused on potassium channels to propose emerging ideas on the role of these channels on pain modulation and to determine whether they can become relevant targets for designing novel analgesic compounds. Two kinds of potassium channels were particularly evoked: selected subunits of the voltage-gated potassium (Kv) and of the K2P channel families. In this review, the role of the former is described with a focus first on silent subunits as modulators of Kv and second on the Kv7 subunits. The physiological, pathophysiological, and pharmacological involvement of the K2P in pain modulation is then described. Throughout this review, the role of potassium channels in pain is obvious, which renders them potential targets for innovative analgesics with peripheral and/or central action depending on the channel. Clearly, some preliminary results obtained with known or novel potassium channel openers suggest that they might represent a novel class of analgesics in neuropathic pain or other pathological contexts.

References

Jan 1, 1988·Pain·James N CampbellSusan E Mackinnon
Mar 28, 1997·The Journal of Biological Chemistry·M SalinasJ P Hugnot
Sep 26, 1997·The Journal of Biological Chemistry·M SalinasM Lazdunski
Aug 4, 1998·The EMBO Journal·A J PatelM Lazdunski
Sep 10, 1999·The Journal of Biological Chemistry·F MaingretE Honoré
Jun 3, 2000·The EMBO Journal·F MaingretE Honoré
Oct 29, 2000·American Journal of Physiology. Renal Physiology·F Lesage, M Lazdunski
Feb 13, 2001·Brain Research. Molecular Brain Research·A D MedhurstM N Pangalos
Aug 17, 2001·Trends in Neurosciences·B Rudy, C J McBain
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·K DedekO K Steinlein
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M N RasbandJ S Trimmer
May 17, 2002·Progress in Neurobiology·Brigitte L Kieffer, Claire Gavériaux-Ruff
Feb 1, 2003·European Journal of Pharmacology·Gordon Blackburn-Munro, Bo Skaaning Jensen
Apr 8, 2003·The Journal of Physiology·Kevin S Thorneloe, Mark T Nelson
Feb 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jérôme J DevauxSteven S Scherer
Mar 10, 2004·Naunyn-Schmiedeberg's Archives of Pharmacology·R DostC Rundfeldt
Jun 15, 2004·Nature Neuroscience·Hiroaki MisonouJames S Trimmer
Jan 29, 2005·The Journal of Physiology·Dawon KangDonghee Kim
Jun 14, 2005·Neurotoxicology·Hiroaki MisonouJames S Trimmer
Aug 3, 2005·Pflügers Archiv : European journal of physiology·Masayuki TakahiraKazuhisa Sugiyama
Aug 17, 2005·Current Pharmaceutical Design·Donghee Kim
May 6, 2006·The EMBO Journal·Abdelkrim AllouiMichel Lazdunski
Aug 15, 2006·Nature Neuroscience·Catherine HeurteauxMichel Lazdunski
Sep 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li-Ying ChienMeei-Ling Tsaur
Oct 1, 2008·Trends in Pharmacological Sciences·Douglas A Bayliss, Paula Q Barrett
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John E LinleyNikita Gamper
Mar 13, 2009·The EMBO Journal·Jacques NoëlMichel Lazdunski
Apr 10, 2009·American Journal of Physiology. Cell Physiology·Elke BocksteinsDirk J Snyders
Aug 12, 2009·Frontiers in Molecular Neuroscience·Thanawath Ratanadilok Na Phuket, Manuel Covarrubias
Apr 16, 2010·Physiological Reviews·Péter Enyedi, Gábor Czirják
Apr 16, 2010·Physiological Reviews·Olaf Pongs, Jürgen R Schwarz

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Citations

Sep 1, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Bálint BotzZsuzsanna Helyes
Jun 10, 2017·Nature Reviews. Drug Discovery·Ajay S YekkiralaClifford J Woolf
Feb 14, 2018·Current Opinion in Supportive and Palliative Care·Fernanda C CardosoRichard J Lewis
Sep 14, 2018·Pain Management·Jessica A Boyette-DavisPatrick M Dougherty
Jan 21, 2017·F1000Research·Halina Machelska, Melih Ö Celik
Mar 4, 2018·Pharmacological Reviews·Sascha R A Alles, Peter A Smith
Sep 14, 2016·The Biochemical Journal·Christoforos TsantoulasPeter A McNaughton
Nov 2, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiangshe WangYuyun Lu
Oct 17, 2017·Journal of Neurology·Ewan St John Smith
Oct 26, 2018·Frontiers in Neuroscience·Deborah ChiabrandoEmanuela Tolosano
May 12, 2019·Neurosurgery·Robert Y NorthPatrick M Dougherty
Sep 19, 2020·Scientific Reports·Jennifer MecklenburgArmen N Akopian
Jun 27, 2019·Pharmaceuticals·Daria A BelinskaiaNatalia N Shestakova
Dec 24, 2018·Brain Sciences·Ryan Thompson, Christina Chan
Aug 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Banulata GopalsamyEnoch Kumar Perimal
Feb 10, 2020·Journal of Neural Transmission·Daniela C RosenbergerRolf-Detlef Treede
Jul 29, 2020·International Journal of Molecular Sciences·Alba Andres-BilbeXavier Gasull
Sep 29, 2020·Frontiers in Cellular Neuroscience·Kseniia KorolevaGuzel Sitdikova
Feb 6, 2021·Neuroscience and Biobehavioral Reviews·Deborah ChiabrandoEmanuela Tolosano
Oct 24, 2020·Frontiers in Cellular Neuroscience·Peter A Smith
Mar 13, 2021·Progress in Neurobiology·Rabia Bouali-BenazzouzPascal Fossat
May 7, 2021·Journal of Medicinal Chemistry·Samuel ObengChristopher R McCurdy
May 19, 2021·Molecular Pain·Mari Aaroe MannerakPer Kristian Eide

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