Potassium channels in pulmonary arterial hypertension

The European Respiratory Journal
Olivier BoucheratSébastien Bonnet

Abstract

Pulmonary arterial hypertension (PAH) is a devastating cardiopulmonary disorder with various origins. All forms of PAH share a common pulmonary arteriopathy characterised by vasoconstriction, remodelling of the pre-capillary pulmonary vessel wall, and in situ thrombosis. Although the pathogenesis of PAH is recognised as a complex and multifactorial process, there is growing evidence that potassium channels dysfunction in pulmonary artery smooth muscle cells is a hallmark of PAH. Besides regulating many physiological functions, reduced potassium channels expression and/or activity have significant effects on PAH establishment and progression. This review describes the molecular mechanisms and physiological consequences of potassium channel modulation. Special emphasis is placed on KCNA5 (Kv1.5) and KCNK3 (TASK1), which are considered to play a central role in determining pulmonary vascular tone and may represent attractive therapeutic targets in the treatment of PAH.

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Citations

Jun 25, 2016·International Journal of Molecular Sciences·Benoît RanchouxSébastien Bonnet
Jun 10, 2017·Pulmonary Circulation·Olivier BoucheratSebastien Bonnet
Jan 31, 2017·Bioorganic & Medicinal Chemistry Letters·Scott E WolkenbergGeorge D Hartman
Jan 24, 2018·Cardiovascular Research·Mélanie LambertFabrice Antigny
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Shuhei TanakaHiroaki Shimokawa
Oct 14, 2017·Journal of the American Heart Association·Simon MalenfantSteeve Provencher
Aug 24, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gema Mondejar-ParreñoAngel Cogolludo
Nov 11, 2017·The European Respiratory Journal·Andrea OlschewskiAlistair Mathie
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Mar 10, 2019·Fundamental & Clinical Pharmacology·Muhammed Fatih DoganKemal Gokhan Ulusoy
Feb 10, 2018·Current Medicinal Chemistry·Valentina MercurioDomenico Bonaduce
May 28, 2019·Hypertension·Conor McClenaghanColin G Nichols
Jul 28, 2019·Circulation Research·Mélanie LambertFabrice Antigny
Jan 8, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sung Eun KimSung Joon Kim
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Dec 12, 2020·American Journal of Respiratory and Critical Care Medicine·Javier Sevilla-MonteroMaría J Calzada
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Jun 19, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Camila Lopez-CrisostoSergio Lavandero
Aug 6, 2021·Scientific Reports·Francisco Perez-VizcainoGema Mondejar-Parreño

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