Potassium channels in T lymphocytes: therapeutic targets for autoimmune disorders?

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Rosane Vianna-Jorge, Guilherme Suarez-Kurtz

Abstract

Human peripheral blood T lymphocytes possess two types of K(+) channels: the voltage-gated Kv1.3 and the calcium-activated IKCa1 channels. The use of peptidyl inhibitors of Kv1.3 and IKCa1 indicated that these channels are involved in the maintenance of membrane potential and that they play a crucial role in Ca(2+) signaling during T-cell activation. Thus, in vitro blockade of Kv1.3 and IKCa1 leads to inhibition of cytokine production and lymphocyte proliferation. These observations prompted several groups of investigators in academia and pharmaceutical companies to characterize the expression of Kv1.3 and IKCa1 in different subsets of human T lymphocytes and to evaluate their potential as novel targets for immunosuppression. Recent in vivo studies showed that chronically activated T lymphocytes involved in the pathogenesis of multiple sclerosis present unusually high expression of Kv1.3 channels and that the treatment with selective Kv1.3 inhibitors can either prevent or ameliorate the symptoms of the disease. In this model of multiple sclerosis, blockade of IKCa1 channels had no effect alone, but improved the response to Kv1.3 inhibitors. In addition, the expression of Kv1.3 and IKCa1 channels in human cells is very restricte...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R J LeonardJ P Reuben
Jan 1, 1990·Advances in Immunology·A AltmanT Mustelin
Aug 1, 1991·Journal of Bioenergetics and Biomembranes·M L GarciaG J Kaczorowski
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S GrissmerK G Chandy
Mar 1, 1990·The Journal of Experimental Medicine·C R MackayL Dudler
Nov 1, 1985·Journal of Neuroimmunology·T E DeCourseyM D Cahalan
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L SchlichterS Hagiwara
Jun 1, 1989·The Journal of General Physiology·S B SandsM D Cahalan
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M PriceC Deutsch
Jan 1, 1985·The Journal of Physiology·M D CahalanS Gupta
Aug 1, 1984·The Journal of Experimental Medicine·K G ChandyS Gupta
Oct 1, 1980·Annals of the Rheumatic Diseases·J A WojtulewskiJ Mason
May 26, 1995·Journal of Medicinal Chemistry·W F MichneD S Krafte
Apr 14, 1995·Science·E A Clark, J S Brugge
Mar 1, 1995·The Plant Cell·L Das, R Martienssen
Jun 1, 1994·Current Biology : CB·M S Diamond, T A Springer
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·A K SimonJ Sieper
Jun 1, 1993·Current Opinion in Immunology·C R Mackay
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A Zweifach, R S Lewis
May 3, 1996·Cell·R Tisch, H McDevitt
Mar 22, 1996·The Journal of Biological Chemistry·K NakahiraJ S Trimmer
May 1, 1996·The Journal of General Physiology·A Zweifach, R S Lewis
Jan 24, 1997·The Journal of Biological Chemistry·R H SpencerK G Chandy
Jul 1, 1997·Journal of Neuroimmunology·M V AutieriM B Prystowsky
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·T M IshiiJ Maylie
Jan 31, 1998·The Journal of Biological Chemistry·N J LogsdonJ Aiyar
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·M D GunnL T Williams
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Apr 29, 1998·Nature·M Baggiolini

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Citations

Aug 15, 2009·Pflügers Archiv : European journal of physiology·Tom Schilling, Claudia Eder
Nov 27, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Howard E GendelmanHuangui Xiong
Sep 15, 2007·Nature Reviews. Immunology·Andrew M ScharenbergDavid J Rawlings
Jul 13, 2007·Biochemical and Biophysical Research Communications·Xin MaoWenxin Li
Feb 24, 2011·Journal of Pharmacological Sciences·Dong Hoon ShinSung Joon Kim
Jan 1, 2013·Journal of Drug Delivery Science and Technology·N H KimO M Merkel
Jan 1, 2011·Journal of Pharmacological Sciences·Dong Hoon ShinSung Joon Kim

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