Potassium channels: newly found players in synaptic plasticity.

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Jinhyun Kim, Dax A Hoffman

Abstract

One of the major issues for modern neuroscience research concerns the molecular and cellular mechanisms that underlie the acquisition, storage, and recollection of memories by the brain. Regulation of the strength of individual synaptic inputs (synaptic plasticity) has, for decades, been the front-running candidate mechanism for cellular information storage, with some direct supporting evidence recently obtained. Research into the molecular mechanisms responsible for changing synaptic strength has, to date, primarily focused on trafficking and properties of the neurotransmitter receptors themselves (AMPARs and NMDARs). However, recent evidence indicates that, subsequent to receptor activation, synaptic inputs are subject to regulation by synaptically located K+ channels. It is therefore critical to understand the biophysical properties and subcellular localization (density and distribution) of these channels and how their properties are modulated. Here we will review recent findings showing that two different classes of K+ channels (A-type and small conductance, Ca2+ -activated K+ channels), beyond their traditional role in regulating action potential firing, contribute to the regulation of synaptic strength in the hippocampus....Continue Reading

References

Feb 1, 1977·The Journal of Physiology·S H Thompson
Feb 1, 1971·The Journal of Physiology·J A Connor, C F Stevens
Dec 1, 1993·Trends in Neurosciences·R C Malenka, R A Nicoll
Mar 1, 1997·Trends in Neurosciences·G StuartM Häusser
Aug 4, 1998·Current Opinion in Neurobiology·C VergaraJ P Adelman
Jul 22, 1999·Annals of the New York Academy of Sciences·W A CoetzeeB Rudy
Jul 22, 1999·Annals of the New York Academy of Sciences·R A Nicoll, R C Malenka
Feb 22, 2000·The Journal of Biological Chemistry·A E AndersonJ D Sweatt
May 16, 2000·The Journal of Physiology·D JohnstonM Migliore
Aug 17, 2001·Trends in Neurosciences·B Rudy, C J McBain
Feb 8, 2002·Neuron·Bernardo L SabatiniKarel Svoboda
May 3, 2002·Nature·Mitsutoshi SetouNobutaka Hirokawa
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shigeo WatanabeDaniel Johnston
Jun 8, 2002·Annual Review of Neuroscience·Roberto Malinow, Robert C Malenka
Jul 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Geert M J Ramakers, Johan F Storm
Feb 20, 2003·Nature Neuroscience·Jacqueline F RiveraDon B Arnold
May 8, 2003·The Journal of Biological Chemistry·Wei-Sheng LeeJohn P Adelman
Jun 28, 2003·The Journal of Biological Chemistry·Riichi ShibataJames S Trimmer
Mar 1, 1961·The Journal of Physiology·S HAGIWARAN SAITO
Sep 23, 2003·The Journal of Physiology·James MaylieJohn P Adelman
Nov 5, 2003·Nature Reviews. Neuroscience·Wei Zhang, David J Linden
Nov 19, 2003·The Journal of Biological Chemistry·Leo A KimSteve A N Goldstein
Dec 18, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Thanos Tzounopoulos, Robert Stackman
Jan 20, 2004·Nature Neuroscience·Andreas FrickDaniel Johnston
Feb 24, 2004·Annual Review of Physiology·James S Trimmer, Kenneth J Rhodes
Apr 7, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·E S Louise Faber, Pankaj Sah
Apr 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew W VargaJ David Sweatt
Jun 11, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chris T BondJohn P Adelman
Sep 30, 2004·Biophysical Journal·Henry H JerngPaul J Pfaffinger
Nov 20, 2004·Nature Reviews. Neuroscience·Kenton J Swartz

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Citations

Feb 11, 2010·European Child & Adolescent Psychiatry·Tobias BanaschewskiDavid Coghill
Jan 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hee Jung ChungLily Yeh Jan
Jul 10, 2013·The Journal of Cell Biology·Natasha M SosanyaKimberly F Raab-Graham
Mar 6, 2009·American Journal of Physiology. Cell Physiology·Linda M BolandErin Casey
Oct 4, 2012·BMC Neuroscience·J Annelies E PolmanNicole A Datson
Oct 4, 2011·PloS One·Ángela Fontán-LozanoAngel Manuel Carrión
Jul 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca S HammondDax A Hoffman
Jan 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lin LinDax A Hoffman
Dec 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brandy N RouthDarrin H Brager
Jan 5, 2010·Molecular and Cellular Neurosciences·Lin LinDax A Hoffman
Dec 15, 2010·CNS Neuroscience & Therapeutics·Khaled RadadWolf-Dieter Rausch
Jun 25, 2009·Journal of Neurochemistry·Gladys Y-P KoMichael L Ko
Jun 5, 2019·Annals of the New York Academy of Sciences·Gregory C JohnsonSayamwong E Hammack
Oct 1, 2010·Reviews in the Neurosciences·Susana Ferrao SantosJean-Noël Octave
Nov 22, 2011·The European Journal of Neuroscience·Katalin KertiZoltan Nusser
Jul 3, 2019·Frontiers in Cellular Neuroscience·Wonjun NohSunggu Yang
Nov 19, 2019·Frontiers in Synaptic Neuroscience·Amita ShresthaOlalekan M Ogundele
Mar 22, 2018·Annals of Clinical and Translational Neurology·Tenpei AkitaHirotomo Saitsu
Aug 22, 2018·Frontiers in Molecular Neuroscience·Benjamin M ZemelTanziyah Muqeem
Mar 3, 2020·Neuroscience·D Fernández-Fernández, J A Lamas
Jun 19, 2019·Molecular and Cellular Neurosciences·G Travis TaborDax A Hoffman
Apr 3, 2010·Progress in Neurobiology·Kate L WeatherallNeil V Marrion
Oct 20, 2021·Cellular and Molecular Life Sciences : CMLS·Lucas MattRobert Lukowski
Jun 16, 2012·Learning & Memory·Bruno TruchetChristiane Mourre

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