PMID: 9632308Jun 19, 1998Paper

Potassium current in Drosophila neurons is increased by either dunce mutation or cyclic AMP

Journal of Neuroscience Research
W B Alshuaib, M V Mathew

Abstract

In the Drosophila mutant dunce, short-term memory is deficient and intracellular cyclic adenosine monophosphate (cAMP) concentration is elevated. We examined the effect of increased cAMP concentration on the potassium current. The conventional whole-cell technique was applied to cultured "giant" Drosophila neurons derived from cell-division arrested embryonic neuroblasts. Potassium membrane currents were measured from: 1) control wild-type neurons, 2) wild-type neurons with dibutyryl cAMP and theophylline in the culture media for 2 days (db-cAMP-treated), and 3) dunce neurons. Delayed-rectifier potassium current was greater in both dunce neurons and db-cAMP-treated wild-type neurons than in control wild-type neurons. This result indicates that the neuronal potassium current is increased by the long-term increase of cAMP. Conceivably, altered neuronal excitability in the dunce mutant could disrupt the processing of neural signals necessary for learning and memory.

Citations

Dec 5, 2002·Learning & Memory·Waleed B Alshuaib, Mini V Mathew
Jun 16, 2004·The International Journal of Neuroscience·Waleed B Alshuaib, Mini V Mathew
Jun 19, 2004·The International Journal of Neuroscience·Waleed B Alshuaib, Mini V Mathew
Jun 19, 2004·The International Journal of Neuroscience·Senol DaneAysenur Aksoy
Jun 19, 2004·The International Journal of Neuroscience·Waleed B AlshuaibMohamed A Fahim
Dec 9, 2003·The International Journal of Neuroscience·Waleed B AlshuaibMohamed A Fahim
Apr 20, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Waleed B Alshuaib, Mini V Mathew
Aug 16, 2006·The Journal of Membrane Biology·Waleed B Alshuaib, Mini V Mathew
Feb 13, 2001·Journal of Neuroscience Research·W B AlshuaibM A Fahim
Mar 29, 2007·Neurochemical Research·Sonia M HasanWaleed B Alshuaib
Nov 18, 2005·Neurochemical Research·Waleed B Alshuaib, Mini V Mathew

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