Potassium currents in submucous neurones of guinea-pig caecum and their synaptic modification.

The Journal of Physiology
T Akasu, T Tokimasa

Abstract

1. Intracellular recordings were made from submucous neurones of the guinea-pig caecum. In most experiments, membrane currents were measured using a single-electrode voltage clamp. 2. A potassium current dependent on calcium influx occurred at rest (approximately equal to 200 pA at -60 mV). The amplitude of the current was increased up to 1 nA at -35 mV and decreased to zero at -100 mV; when fully activated the current did not show any inactivation. An inward calcium current, of 15-25 pA in amplitude near -60 mV and insensitive to omega-conotoxin (0.5 microM), probably activated the potassium current. 3. Step depolarizations from potentials negative to -80 mV evoked a transient (less than or equal to 200 ms at -40 mV) potassium current which was blocked by 4-aminopyridine (1-3 mM). Hyperpolarizing commands to potentials negative to -87 mV evoked an inwardly rectifying potassium current which was selectively blocked by caesium (1-2 mM). The residual cell current between -100 and -40 mV in calcium-free solution containing tetraethylammonium (20 mM), caesium (2 mM) and 4-amino-pyridine (3 mM) conformed to constant field assumptions. This current was called a background potassium current. 4. Decrease in membrane conductance during ...Continue Reading

Citations

May 1, 1993·Progress in Neurobiology·S Mihara
Sep 1, 1993·Pflügers Archiv : European journal of physiology·C Barajas-López
Nov 1, 1994·The American Journal of Physiology·C Barajas-López
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
May 4, 1995·Regulatory Peptides·U Holzer-Petsche

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