Abstract
The hemodynamic effect of moderate K+ depletion in hypertension is unknown. Since severe K+ depletion reduces systemic vascular resistance in normotensive rats, we determined the effect of K+ depletion on the natural history of hypertension in spontaneously hypertensive rats (SHR). Wistar-Kyoto rats (WKY) and SHR were fed a K+-replete, a moderately K+-depleted, or a severely K+-depleted diet. After 6 weeks, systemic vascular resistance was reduced by 25% in WKY on the severely K+-depleted diet while mean arterial pressure and systemic vascular resistance were comparable in WKY on the other two diets. In SHR on the severely K+-depleted diet for 6 weeks, muscle K+ was reduced by 23% and growth rate by 65%. In SHR on the moderately K+-depleted diet, growth rate was reduced by 23% after 3 weeks. By 6 weeks, however, muscle K+ was reduced by 5 to 6% and growth rate was comparable to that in SHR receiving the K+-replete diet. The administration of either K+-depleted diet prevented the development of hypertension (systolic blood pressure: severely depleted, 116 +/- 4; moderately depleted, 122 +/- 3; K+-replete, 155 +/- 5 mm Hg; p less than 0.001 compared with both K+-depleted groups) and reversed established hypertension (systolic blo...Continue Reading
References
Feb 1, 1975·Circulation Research·H GavrasI Gavras
Nov 1, 1979·Pflügers Archiv : European journal of physiology·A Mimran, D Casellas
Nov 23, 1976·The American Journal of Cardiology·G R Meneely, H D Battarbee
Dec 1, 1977·The American Journal of Cardiology·J F Spear, E N Moore
Oct 1, 1985·Kidney International·R G Benedetti, S L Linas
May 1, 1971·American Heart Journal·R C Bahler, L Rakita
Jan 1, 1968·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·P KonoldK Brecht
Mar 11, 1967·The American Journal of Physiology·N S Skinner, W J Powell
Jan 10, 1981·Lancet·P S ParfreyJ M Ledingham
Sep 11, 1982·Lancet·G A MacGregorG A Sagnella
May 1, 1982·Kidney International·S L Linas, D Dickmann
Mar 30, 1984·Science·S A WhitescarverT A Kotchen
Nov 5, 1984·The American Journal of Medicine·J P Knochel
Dec 9, 1983·Science·T W Kurtz, R C Morris
Jan 1, 1984·The Journal of Clinical Investigation·M S PallerS L Linas
Jul 1, 1984·The American Journal of Medicine·N M Kaplan
Aug 15, 1981·British Medical Journal·A F LeverJ I Robertson
May 1, 1983·Annals of Internal Medicine·H G Langford
Sep 1, 1982·Clinical Science·C Beretta-PiccoliE D Williams
Jul 16, 1982·Science·D A McCarronC Cole
Mar 1, 1980·Pflügers Archiv : European journal of physiology·S L LinasR J Anderson
Apr 1, 1981·The American Journal of Medicine·O B HollandL Kuhnert
Sep 1, 1981·Hypertension·H SuzukiT Saruta
Mar 1, 1981·Circulation Research·N C Trippodo, E D Frohlich
Dec 1, 1953·The American Journal of Physiology·R H ROSENMANM K SMITH
Feb 1, 1963·The American Journal of Physiology·F J HADDYJ N HUIZENGA
Citations
Jan 1, 1993·Life Sciences·W R WelchesC M Ferrario
Apr 25, 2001·Kidney International·P E RayR J Johnson
Aug 1, 1995·Clinical and Experimental Hypertension : CHE·X WuH Sonnenberg
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·M Li, J A Whitworth
Jan 1, 1991·Annals of the New York Academy of Sciences·R R Llinás
Jun 14, 1993·Annals of the New York Academy of Sciences·M M MerzenichX Wang
Jun 14, 1993·Annals of the New York Academy of Sciences·P K Kuhl
Jul 1, 1988·Kidney International·S L LinasR F O'Brien
Apr 1, 1991·Kidney International·S L Linas
Aug 27, 2016·Pflügers Archiv : European journal of physiology·Christine WalterGilles Crambert
May 4, 1989·The New England Journal of Medicine·G G KrishnaS Kapoor
Jun 14, 1993·Annals of the New York Academy of Sciences·P TallalR H Fitch
Jun 5, 1998·The American Journal of Physiology·J I ShapiroN Elkins
Oct 21, 2000·Renal Failure·Z XieJ I Shapiro
Nov 1, 1994·Nutrition Reviews·M E Reusser, D A McCarron
May 1, 1990·The American Journal of Physiology·S L LinasM E Ullian
Apr 14, 2020·American Journal of Physiology. Renal Physiology·Cary R Boyd-ShiwarskiArohan R Subramanya
Apr 7, 2000·Journal of the American Society of Nephrology : JASN·Hassan N Ibrahim, Thomas H Hostetter