Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways

European Journal of Immunology
Jack Rivers-Auty, David Brough

Abstract

Murine caspase-11 and its human orthologues, caspase-4 and caspase-5, activate an inflammatory response following cytoplasmic recognition of cell wall constituents from Gram-negative bacteria, such as LPS. This inflammatory response involves pyroptotic cell death and the concomitant release of IL-1α, as well as the production of IL-1β and IL-18 through the noncanonical NLR family, pyrin domain containing 3 (NLRP3) pathway. This commentary discusses three papers in this issue of the European Journal of Immunology that advance our understanding of the roles of caspase-11, -4, and -5 in the noncanonical pathway. By utilizing the new gene editing technique, clustered regularly interspaced short palindromic repeats (CRISPR), as well as sensitive cell imaging techniques, these papers establish that cytoplasmic LPS-dependent IL-1β production requires the NLRP3 inflammasome and that its activation is dependent on K(+) efflux, whereas IL-1α release and pyroptotic cell death pathways are NLRP3-independent. These findings expand on previous research implicating K(+) efflux as the principal trigger for NLRP3 activation and suggest that canonical and noncanonical NLRP3 pathways are not as dissimilar as first thought.

References

Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
Jan 17, 2009·Nature Reviews. Microbiology·Tessa BergsbakenBrad T Cookson
Mar 5, 2010·European Journal of Immunology·Veit Hornung, Eicke Latz
Oct 18, 2011·Nature·Nobuhiko KayagakiVishva M Dixit
Sep 6, 2012·The Journal of Biological Chemistry·Christine JulianaEmad S Alnemri
Dec 5, 2012·The Journal of Biological Chemistry·Gloria Lopez-CastejonDavid Brough
Dec 19, 2012·Molecular Cell·Bénédicte F PyJunying Yuan
May 25, 2013·Nature Reviews. Immunology·Eicke LatzAndrea Stutz
Sep 17, 2013·European Journal of Immunology·Elena Viganò, Alessandra Mortellaro
Sep 24, 2013·Immunity·Haitao WenJenny P-Y Ting
Oct 18, 2014·Cold Spring Harbor Perspectives in Biology·Marcel R de ZoeteRichard A Flavell
Jan 2, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vincent CompanPablo Pelegrín
Feb 6, 2015·Journal of Inflammation Research·Ema OzakiSarah L Doyle
Jul 16, 2015·European Journal of Immunology·Sebastian Rühl, Petr Broz
Jul 16, 2015·European Journal of Immunology·Paul J BakerSeth L Masters
Jul 16, 2015·European Journal of Immunology·Jonathan L Schmid-BurgkVeit Hornung

❮ Previous
Next ❯

Citations

Mar 26, 2016·Frontiers in Immunology·Julie Guignot, Guy Tran Van Nhieu
Apr 30, 2016·Oxidative Medicine and Cellular Longevity·Letteria MinutoliDomenica Altavilla
Dec 17, 2014·Trends in Molecular Medicine·Prajwal GurungThirumala-Devi Kanneganti
Dec 23, 2016·Brain Pathology·Claire S WhiteJack Rivers-Auty
Mar 3, 2020·Journal of Cellular Physiology·Sachiko WatanabeMasafumi Takahashi
Feb 6, 2020·Experimental and Therapeutic Medicine·Qingxin YangNan Zeng
Nov 23, 2016·Human Genomics·Rita M C de AlmeidaRobert L Bacallao
Mar 22, 2018·Nature Communications·Jack Rivers-AutyDavid Brough
Sep 16, 2020·Nature Communications·Larissa M N PereiraRicardo T Gazzinelli
Jan 8, 2021·International Journal of Molecular Sciences·Kohsuke Tsuchiya
Jul 25, 2021·International Journal of Molecular Sciences·Young-Su Yi
Aug 4, 2021·Acta Pharmacologica Sinica·Xiao-Yan WuPing-Zheng Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

CRISPR for Genome Editing

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.