Abstract
Murine caspase-11 and its human orthologues, caspase-4 and caspase-5, activate an inflammatory response following cytoplasmic recognition of cell wall constituents from Gram-negative bacteria, such as LPS. This inflammatory response involves pyroptotic cell death and the concomitant release of IL-1α, as well as the production of IL-1β and IL-18 through the noncanonical NLR family, pyrin domain containing 3 (NLRP3) pathway. This commentary discusses three papers in this issue of the European Journal of Immunology that advance our understanding of the roles of caspase-11, -4, and -5 in the noncanonical pathway. By utilizing the new gene editing technique, clustered regularly interspaced short palindromic repeats (CRISPR), as well as sensitive cell imaging techniques, these papers establish that cytoplasmic LPS-dependent IL-1β production requires the NLRP3 inflammasome and that its activation is dependent on K(+) efflux, whereas IL-1α release and pyroptotic cell death pathways are NLRP3-independent. These findings expand on previous research implicating K(+) efflux as the principal trigger for NLRP3 activation and suggest that canonical and noncanonical NLRP3 pathways are not as dissimilar as first thought.
References
Mar 31, 1995·Science·K KuidaR A Flavell
Feb 10, 1995·Cell·P LiJ Salfeld
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
Jan 17, 2009·Nature Reviews. Microbiology·Tessa BergsbakenBrad T Cookson
Mar 5, 2010·European Journal of Immunology·Veit Hornung, Eicke Latz
Oct 18, 2011·Nature·Nobuhiko KayagakiVishva M Dixit
Feb 22, 2012·Immunity·Kenichi ShimadaMoshe Arditi
Mar 27, 2012·Immunity·Olaf GrossJurg Tschopp
Jul 24, 2012·Cell·Vijay A K RathinamKatherine A Fitzgerald
Sep 6, 2012·The Journal of Biological Chemistry·Christine JulianaEmad S Alnemri
Dec 5, 2012·The Journal of Biological Chemistry·Gloria Lopez-CastejonDavid Brough
Dec 19, 2012·Molecular Cell·Bénédicte F PyJunying Yuan
May 25, 2013·Nature Reviews. Immunology·Eicke LatzAndrea Stutz
Jul 3, 2013·Immunity·Raúl Muñoz-PlanilloGabriel Núñez
Sep 14, 2013·Science·Jon A HagarEdward A Miao
Sep 17, 2013·European Journal of Immunology·Elena Viganò, Alessandra Mortellaro
Sep 24, 2013·Immunity·Haitao WenJenny P-Y Ting
Mar 19, 2014·Cell·Alvin LuEdward H Egelman
Mar 19, 2014·Cell·Xin CaiZhijian J Chen
Aug 15, 2014·Nature·Jianjin ShiFeng Shao
Oct 18, 2014·Cold Spring Harbor Perspectives in Biology·Marcel R de ZoeteRichard A Flavell
Jan 2, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vincent CompanPablo Pelegrín
Feb 6, 2015·Journal of Inflammation Research·Ema OzakiSarah L Doyle
Feb 17, 2015·Nature Medicine·Rebecca C CollLuke A J O'Neill
Jul 16, 2015·European Journal of Immunology·Sebastian Rühl, Petr Broz
Jul 16, 2015·European Journal of Immunology·Paul J BakerSeth L Masters
Jul 16, 2015·European Journal of Immunology·Jonathan L Schmid-BurgkVeit Hornung
Citations
Mar 26, 2016·Frontiers in Immunology·Julie Guignot, Guy Tran Van Nhieu
Apr 30, 2016·Oxidative Medicine and Cellular Longevity·Letteria MinutoliDomenica Altavilla
Dec 17, 2014·Trends in Molecular Medicine·Prajwal GurungThirumala-Devi Kanneganti
Jan 23, 2017·Brain, Behavior, and Immunity·Mark R ZielinskiRadhika Basheer
Dec 23, 2016·Brain Pathology·Claire S WhiteJack Rivers-Auty
Oct 21, 2019·Immunology·Young-Su Yi
Jan 9, 2020·Microbiology and Immunology·Kohsuke Tsuchiya
Mar 3, 2020·Journal of Cellular Physiology·Sachiko WatanabeMasafumi Takahashi
Feb 6, 2020·Experimental and Therapeutic Medicine·Qingxin YangNan Zeng
Nov 23, 2016·Human Genomics·Rita M C de AlmeidaRobert L Bacallao
Sep 19, 2019·ELife·Thomas ScamblerMichael F McDermott
Mar 22, 2018·Nature Communications·Jack Rivers-AutyDavid Brough
Sep 16, 2020·Nature Communications·Larissa M N PereiraRicardo T Gazzinelli
Jan 12, 2021·Frontiers in Immunology·Ziwei XuPingzheng Zhou
Jan 8, 2021·International Journal of Molecular Sciences·Kohsuke Tsuchiya
Mar 25, 2021·Cell Reports·Kohsuke TsuchiyaTakashi Suda
May 22, 2021·Frontiers in Immunology·Fengqing HouRendong Fang
Jun 12, 2021·BioTechniques·Ian P BreschSusanne Eschenburg
Jul 25, 2021·International Journal of Molecular Sciences·Young-Su Yi
Aug 4, 2021·Acta Pharmacologica Sinica·Xiao-Yan WuPing-Zheng Zhou