PMID: 7035673Jan 1, 1982Paper

Potassium-induced insulin release and voltage noise measurements in single mouse islets of Langerhans

The Journal of Membrane Biology
C M DawsonE Rojas

Abstract

Insulin release and membrane potential fluctuations in response to increased extracellular potassium [K+]o have been measured in single perifused islets of Langerhans from normal mice. An increase in [K+]o from 5 mM to 50 mM induced a transient insulin release with a peak at about 1 min. The peak value was [K+]o-dependent but the half-time t1/2 for the decline was constant at nearly 1 min. 2.5 mM cobalt completely inhibited the potassium-induced stimulation of insulin release. The insulin release elicited by 28 and 50 mM [K+]o was similar in terms of peak, total release and half-time from maximum release. Stepwise increase in [K+]o from 10 to 28 to 50 mM resulted in a normal response to 28 mM but no peak of release after the 28 to 50 mM increase. The results indicate good correlation between excess voltage noise, thought to reflect calcium channel activity, and insulin release evoked by changing extracellular potassium.

References

Sep 1, 1978·The Journal of Clinical Investigation·B J FrankelG M Grodsky
Oct 1, 1978·FEBS Letters·H P MeissnerM Preissler
Dec 28, 1978·Pflügers Archiv : European journal of physiology·B HellmanI B Täljedal
Jan 1, 1976·The Journal of Physiology·B HellmanI B Täljedal
Mar 1, 1975·The Journal of Physiology·E K Matthews, Y Sakamoto
Jun 1, 1975·The American Journal of Physiology·J C Henquin, A E Lambert
Jan 1, 1972·Progress in Biophysics and Molecular Biology·P F Baker
Jun 1, 1968·The Biochemical Journal·S L Howell, K W Taylor
Apr 20, 1973·Nature·H M BarkerA Gunn
Jan 1, 1974·Pflügers Archiv : European journal of physiology·H P Meissner, H Schmelz
Apr 1, 1973·Endocrinology·M Gomez, D L Curry
Jun 1, 1973·The Journal of Physiology·P F BakerE B Ridgway
Mar 1, 1971·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W J MalaisseG Brisson
Sep 1, 1970·The Journal of Physiology·P M Dean, E K Matthews
Feb 1, 1968·The Journal of Physiology·C N Hales, R D Milner
Jan 3, 1968·Biochimica Et Biophysica Acta·R D Milner, C N Hales
Jan 1, 1967·The Journal of General Physiology·S Hagiwara, K Takahashi
Mar 20, 1959·The Journal of General Physiology·C P BIANCHI, A M SHANES
Nov 1, 1961·The Journal of Physiology·W W DOUGLAS, R P RUBIN
Jul 1, 1963·The Biochemical Journal·C N HALES, P J RANDLE
Jan 26, 1963·Lancet·C N HALES, P J RANDLE
Oct 1, 1959·The Journal of Physiology·A L HODGKIN, P HOROWICZ
Mar 3, 1949·The Journal of Physiology·A L HODGKIN, B KATZ
Sep 20, 1943·The Journal of General Physiology·D E Goldman

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Citations

Jan 1, 1983·The Journal of Membrane Biology·R Latorre, C Miller
Dec 5, 2015·Journal of Physiology and Biochemistry·Cem EkmekciogluThomas Moeslinger
Nov 1, 1984·British Journal of Pharmacology·E K Matthews, P A Shotton
Apr 1, 1984·Pflügers Archiv : European journal of physiology·A Grosso, R C de Sousa
Nov 1, 1982·Pflügers Archiv : European journal of physiology·A GrossoR C de Sousa
Oct 29, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Ibrahim ElmadfaCem Ekmekcioglu
Jan 1, 1984·The American Journal of Physiology·C B Wollheim, D Janjic

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