PMID: 9422357Jan 9, 1998Paper

Potassium-induced release of endogenous morphine from rat brain slices

Journal of Neurochemistry
M GuarnaE Bianchi

Abstract

Endogenous morphine has been clearly demonstrated by gas chromatography/mass spectrometry in the brain, spinal fluid, adrenal glands, and liver of mammals. To clarify the role of endogenous morphine, its release from rat brain slices was studied in vitro in the presence of high potassium concentrations, with and without calcium in the medium. The perfusate was hydrolyzed, solid phase-extracted, and then analyzed by gas chromatography/mass spectrometry. Depolarization due to high potassium concentrations increased the release of the alkaloid manyfold with respect to the basal value, and the release was dependent on the presence of calcium in the medium. These results suggest that endogenous morphine might act as a neurotransmitter or neuromodulator in the rat CNS.

Citations

Mar 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Tobias Esch, George B Stefano
Mar 11, 2008·PloS One·Arnaud MullerYannick Goumon
Apr 12, 2000·European Journal of Biochemistry·V LaurentM Salzet
Jul 23, 2008·Journal of Neurochemistry·Carla NeriEnrica Bianchi
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chotima PoeaknapoMeinhart H Zenk
Jul 16, 2005·Expert Opinion on Biological Therapy·Stephen C PryorGeorge B Stefano
Sep 9, 2008·Neurochemical Research·George B StefanoWei Zhu

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