Potassium-induced release of enkephalins from rat striatal slices

European Journal of Pharmacology
H OsborneA Herz

Abstract

The rate of release of enkephalin from rat striatal slices increased 7--10 fold in response to depolarization by 50 mM potassium ions in vitro. The potassium-evoked release of enkephalins was abolished in a calcium deficient medium. Uptake studies indicated that the potassium-stimulated efflux was not due to the inhibition of an active uptake mechanism for these peptides. These findings provide support for the view that enkephalins may function as neurotransmitters in brain.

References

Mar 31, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E Habermann
Apr 1, 1977·Neuropharmacology·H Y YangE Costa
Aug 1, 1976·European Journal of Pharmacology·H D TaubeK Starke
Jun 15, 1975·Life Sciences·G W PasternakS H Snyder
May 14, 1976·Brain Research·R SimantovS H Snyder

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Citations

Oct 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·T DukaA Herz
Jan 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·H Osborne, A Herz
Jan 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·J A García-SevillaA Carlsson
Feb 20, 1984·Brain Research·G PasinettiM Trabucchi
Sep 15, 1979·European Journal of Pharmacology·W R Buckett
May 15, 1979·European Journal of Pharmacology·H OsborneA Herz
May 16, 1980·European Journal of Pharmacology·T L Yaksh, R P Elde
May 22, 1981·European Journal of Pharmacology·M Laubie, H Schmitt
Jul 1, 1982·Neuropharmacology·M R CarratùD Mitolo-Chieppa
Jan 1, 1982·Progress in Neurobiology·R C Frederickson, L E Geary
Jan 1, 1981·Neuroscience·F CesselinM Hamon
Feb 1, 1983·Journal of Neurochemistry·C A Jones, R M Marchbanks
Feb 1, 1981·Journal of Neurochemistry·I Lindberg, J L Dahl
Jan 1, 1982·Annals of the New York Academy of Sciences·E J Simon
Jul 15, 1979·Klinische Wochenschrift·K Kuschinsky

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