PMID: 3214676Sep 1, 1988Paper

Potassium ion ionization of desorbed species (K+IDS): a rapid method for the screening of urine for organic acidemias

Biomedical & Environmental Mass Spectrometry
D B Kassel, J Allison

Abstract

A new desorption/ionization mass spectrometric technique, K+ ionization of desorbed species (K+IDS), is evaluated as a rapid method for differentiating various organic acidemias, conditions in which excessive levels of organic acid metabolites are present in plasma or urine as a result of some inborn error of metabolism. This method requires no derivatization of the isolated organic acids, unlike that required for gas chromatographic and gas chromatographic/mass spectrometric analyses. 'Batch' mass spectrometric analysis is achieved by deposition of the complex organic acid mixture (from urine) onto a K+IDS probe. Rapid heating results in the emission of alkali ions (Na+ or K+) from a thermionic emitter and the intact desorption of analyte. Subsequent gas-phase addition produces a mass spectrum showing alkali ion adducts of the components, providing molecular weight and relative concentration information. This rapid desorption/ionization technique requires no matrix, and analysis times are exceedingly short relative to those required in gas chromatographic/mass spectrometric analyses. Results suggest that differential diagnosis of some of the more commonly occurring organic acidemias (e.g. isovaleric acidemia, maple syrup urine...Continue Reading

References

Jun 1, 1977·Developmental Medicine and Child Neurology·J P Van BiervlietL A Monnens
Feb 1, 1979·Biomedical Mass Spectrometry·D Issachar, J Yinon
Jun 20, 1986·Journal of Chromatography·J F HollandC C Sweeley
Jan 1, 1987·The International Journal of Biochemistry·T Page, W L Nyhan
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W J Rhead, K Tanaka

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Citations

Jun 15, 2018·Journal of Personality Assessment·Abby L MulayRebecca Skadberg
Nov 1, 1996·Medical & Biological Engineering & Computing·P Spanĕl, D Smith

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