Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats

Cancer Science
Mohamed AbdelgiedSatoru Takahashi

Abstract

Potassium octatitanate fibers (K2 O·8TiO2 , POT fibers) are widely used as an alternative to asbestos. We investigated the pulmonary and pleural toxicity of POT fibers with reference to 2 non-fibrous titanium dioxide nanoparticles (nTiO2 ), photoreactive anatase (a-nTiO2 ) and inert rutile (r-nTiO2 ). Ten-week-old male F344 rats were given 0.5 mL of 250 μg/mL suspensions of POT fibers, a-nTiO2 , or r-nTiO2 , 8 times (1 mg/rat) over a 15-day period by trans-tracheal intrapulmonary spraying (TIPS). Rats were killed at 6 hours and at 4 weeks after the last TIPS dose. Alveolar macrophages were significantly increased in all treatment groups at 6 hours and at 4 weeks. At week 4, a-nTiO2 and r-nTiO2 were largely cleared from the lung whereas a major fraction of POT fibers were not cleared. In the bronchoalveolar lavage, alkaline phosphatase activity was elevated in all treatment groups, and lactate dehydrogenase (LDH) activity was elevated in the a-nTiO2 and POT groups. In lung tissue, oxidative stress index and proliferating cell nuclear antigen (PCNA) index were elevated in the a-nTiO2 and POT groups, and there was a significant elevation in C-C motif chemokine ligand 2 (CCL2) mRNA and protein in the POT group. In pleural cavity la...Continue Reading

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Citations

Oct 21, 2018·Archives of Toxicology·Ahmed M El-GazzarHiroyuki Tsuda
Sep 10, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hajime TanakaHiroyuki Tsuda
Oct 21, 2020·Nanomaterials·Chinatsu NishidaYasuo Morimoto
Feb 26, 2021·Journal of Toxicologic Pathology·Takamasa NumanoYuji Hagiwara
Sep 30, 2021·Scientific Reports·Nobuaki NegishiSetsuko Koura

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Methods Mentioned

BETA
transmission electron microscopy
X‐ray
bronchoalveolar lavage
light microscopy
lavage
Protein Assay
bronchoalveolar
chip
PCR
ELISA

Software Mentioned

SPSS
NIH image analyzer
Primer Premier

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