PMID: 6286478Sep 1, 1982Paper

Potassium relaxation of vascular smooth muscle from DOCA hypertensive pigs

Hypertension
R C Webb

Abstract

This study was designed to characterize potassium-induced relaxation in vascular smooth muscle during the development of deoxycorticosterone acetate (DOCA) hypertension. Pigs were implanted subcutaneously with 100 mg/kg DOCA. Mean arterial pressure in the DOCA-treated pigs reached levels approximately 37% greater than controls. In some pigs, the left hindlimb vascular bed was "protected" from the rise in arterial pressure by ligation of the iliac artery. Arterial strips from DOCA hypertensive and normotensive pigs relaxed in response to potassium after contraction induced by norepinephrine in potassium-free solution. Arterial strips from DOCA hypertensive pigs showed greater relaxation than did those from normotensive pigs. The magnitude of relaxation in femoral arteries from "protected" hindlimbs was similar to that in arteries from the contralateral unoccluded limb. Potassium-induced relaxation in tail arteries from DOCA hypertensive pigs was more sensitive to ouabain inhibition than that from normotensive pigs. Relaxation induced by potassium varied with: 1) length of incubation in potassium-free solution; 2) concentration of added potassium; and 3) concentration of norepinephrine added during the potassium-free interval. Th...Continue Reading

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Citations

Jan 1, 1983·Pflügers Archiv : European journal of physiology·R C WebbD F Bohr
Feb 1, 1984·Pflügers Archiv : European journal of physiology·M KesterM Bárány
Apr 12, 2011·Acta Physiologica·L MagnussonM Salomonsson
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·K YamamotoM Nakamura
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·S Matsuda, N Aoki
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·B A ScogginsJ P Coghlan
Sep 1, 1992·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·G Rinaldi, D F Bohr
Apr 1, 1988·The American Journal of the Medical Sciences·G Rinaldi, D Bohr
Oct 1, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Ursula ReiterMichael Fuchsjäger
Jan 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·C G Sobey
Jul 1, 1983·Hypertension·D R Harder, K Hermsmeyer

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