PMID: 2596940Dec 1, 1989Paper

Potassium restoration in hypertensive patients made hypokalemic by hydrochlorothiazide

Archives of Internal Medicine
H W SchnaperF G McMahon

Abstract

Among 447 hypertensive patients, most with a history of diuretic-induced hypokalemia, 252 developed diuretic-induced hypokalemia while receiving hydrochlorothiazide, 50 mg/d. In a randomized study we evaluated the efficacy of three drug regimens in restoring potassium levels while maintaining blood pressure control: hydrochlorothiazide (50 mg/d) plus potassium supplement (20 mmol/d); hydrochlorothiazide (50 mg/d) plus potassium supplement (40 mmol/d); or hydrochlorothiazide (50 mg/d) with triamterene (75 mg/d) in one combination tablet. In all groups, mean serum levels of potassium rose within 1 week and showed no further change thereafter. However, the hydrochlorothiazide/triamterene and hydrochlorothiazide plus 40 mmol of potassium regimens were significantly more effective in restoring serum potassium levels than was the hydrochlorothiazide plus 20 mmol of potassium regimen. A significant increase in magnesium levels was observed only in the group treated with the hydrochlorothiazide/triamterene combination. Each regimen provided continued control of mild to moderate hypertension.

Citations

Jan 26, 2010·Expert Opinion on Drug Safety·Pantelis A SarafidisAnastasios N Lasaridis
Jul 22, 2015·Journal of General Internal Medicine·Wanzhu TuJ Howard Pratt
Feb 6, 2013·American Journal of Hypertension·Linda M GerberPenny H Feldman
Apr 7, 2010·Journal of Evaluation in Clinical Practice·Stephen Ayre, Gareth Walters
Jan 24, 2004·Journal of Cardiovascular Pharmacology and Therapeutics·G MiltiadousM Elisaf
Dec 31, 2014·Journal of the Chinese Medical Association : JCMA·Chern-En ChiangShing-Jong Lin
Sep 30, 2008·International Journal of Clinical Practice·G LiamisM Elisaf

Related Concepts

Sectrazide
Hypertensive Disease
Hypokalemia
Magnesium
Patient Non-Compliance
Potassium
Randomization

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