PMID: 6980989Jan 1, 1982Paper

Potassium transport across the frog retinal pigment epithelium

The Journal of Membrane Biology
S S Miller, R H Steinberg

Abstract

Previous experiments indicate that the apical membrane of the frog retinal pigment epithelium contains electrogenic Na:K pumps. In the present experiments net potassium and rubidium transport across the epithelium was measured as a function of extracellular potassium (rubidium) concentration, [K]0 ( [Rb]0). The net rate of retina-to-choroid 42K(86Rb) transport increased monotonically as [K]0 ( [Rb]0) increased from approximately 0.2 to 5 mM on both sides of the tissue or on the apical (neural retinal) side of the tissue. No further increase was observed when [K]0 ( [Rb]0) was elevated to 10 mM. Net sodium transport was also stimulated by elevating [K]0. The net K transport was completely inhibited by 10-4 M ouabain in the solution bathing the apical membrane. Ouabain inhibited the unidirectional K flux in the direction of net flux but had no effect on the back-flux in the choroid-to-retina direction. The magnitude of the ouabain-inhibitable 42K(86Rb) flux increased with [K]0 ( [Rb]0). These results show that the apical membrane Na:K pumps play an important role in the net active transport of potassium (rubidium) across the epithelium. The [K]0 changes that modulate potassium transport coincide with the light-induced [K]0 change...Continue Reading

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Citations

Oct 15, 1985·Documenta Ophthalmologica. Advances in Ophthalmology·R H Steinberg
Apr 1, 1992·Pflügers Archiv : European journal of physiology·J A Fox, R H Steinberg
Jan 1, 1988·Pflügers Archiv : European journal of physiology·S K KellerM Wiederholt
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Feb 1, 1992·The Journal of General Physiology·D P Joseph, S S Miller
Mar 2, 2006·Assay and Drug Development Technologies·Khuram W ChaudharyAnthony Bahinski
Jun 1, 1992·Experimental Eye Research·M La Cour
Oct 1, 1986·Experimental Eye Research·P A Sellner
Mar 15, 2006·Experimental Eye Research·Henry K W FongSujay Pandey
Aug 1, 1997·Experimental Eye Research·U SchraermeyerK Heimann
Feb 7, 2003·American Journal of Physiology. Cell Physiology·Sigrid A RajasekaranAyyappan K Rajasekaran
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Apr 1, 1994·The American Journal of Physiology·J L EdelmanS S Miller
Jan 1, 1988·The American Journal of Physiology·B A HughesJ L Edelman
Apr 1, 1987·The American Journal of Physiology·B A HughesD B Farber

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