PMID: 869248Jul 1, 1977Paper

Potencies of neuromuscular blocking agents at the receptors of the atrial pacemaker and the motor endplate of the guinea pig

Anesthesiology
S L Son, B E Waud

Abstract

Drug receptor dissociation constants (KB) were determined for four neuromuscular relaxants at the cardiac pacemaker as well as at the motor endplate. The ratios KB(atrium)/KB(lumbrical) were found to be high for d-tubocurarine and dimethyltubocurarine, 264 and 136, respectively. Thus, interaction at muscarinic sites would occur only with large doses of these drugs. In contrast, the ratios were low for pancuronium and gallamine, 5.3 and 2.4, respectively. Hence, the concentrations of these drugs needed for clinical neuromuscular blockade would occupy appreciable fractions of cardiac muscarinic receptors, and thus might produce vagal blockade and thereby produce the tachycardia seen clinically with these two agents.

Citations

Mar 18, 2000·Pharmacology & Therapeutics·K N Bradley
Jan 1, 1979·Anaesthesia·Y HashimotoM Satou
May 1, 1993·Acta Anaesthesiologica Scandinavica·K OmoteA Namiki
Aug 1, 1979·The Journal of Pharmacy and Pharmacology·P TeerapongN K Ahuja
Feb 1, 1982·The Journal of Pediatrics·D K RaschR Reddi
Jul 6, 2014·Veterinary Anaesthesia and Analgesia·Kristoffer GrongGeir O Dahle

Related Concepts

Chemoreceptor Cells
Dose-Response Relationship, Drug
Gallamine
Right Atrial Structure
Cardiac Conduction System
Motor Endplate
Muscle
Neuromuscular Blocking Agents
Nerve-Muscle Preparation
Pancuronium Curamed

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