Potency and selectivity in vitro of compounds related to isoprenaline and orciprenaline on beta-adrenoceptors in the guinea-pig

British Journal of Pharmacology
S R O'Donnell, J C Wanstall


1 Amines related in structure to either isoprenaline (catechol series) or orciprenaline (resorcinol series) were examined for activity on isolated trachea (relaxation), atria (chronotropic action) and perfused hind-limb (vasodilatation) of the guinea-pig.2 Compounds with a resorcinol nucleus were less potent on all three preparations but more selective for trachea than were compounds with a catechol nucleus.3 In both catechol and resorcinol compounds potency on trachea was enhanced by and selectivity for trachea was favoured by substitution of a p-OH phenyl group in the N-iso propyl, or by replacement of the N-iso propyl with an N-t-butyl, with or without a p-OH phenyl group.4 Most of the compounds, particularly the resorcinols, had much lower potencies, relative to isoprenaline, on hind-limb than on trachea.5 Some of the problems associated with the quantitative measurement of selectivity and with sub-classification of beta-adrenoceptors are discussed.


Oct 1, 1965·The Australian Journal of Experimental Biology and Medical Science·I S De la Lande, M J Rand
Feb 1, 1970·British Journal of Pharmacology·F Fogelman, H F Grundy
Sep 1, 1970·European Journal of Pharmacology·S R O'Donnell
Feb 10, 1967·Annals of the New York Academy of Sciences·R F Furchgott
Nov 1, 1967·European Journal of Pharmacology·L A Chahl, S R O'Donnell
Jan 1, 1969·British Journal of Pharmacology·V A CullumG P Levy
Nov 1, 1967·Life Sciences·A M LandsH J Buzzo


Dec 5, 1980·European Journal of Pharmacology·V J LottiP Kling
Jan 1, 1976·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·R T BrittainD Jack
Jul 1, 1978·British Journal of Clinical Pharmacology·M I BlackhallS R O'Donnell
Feb 1, 1992·British Journal of Clinical Pharmacology·B J Lipworth, D G McDevitt
Nov 1, 1975·Clinical and Experimental Pharmacology & Physiology·S R O'Donnell, J C Wanstall
Jul 1, 1978·Clinical and Experimental Pharmacology & Physiology·G S KehH Dowd
Aug 1, 1980·Journal of Pharmacological Methods·S R O'Donnell, J C Wanstall
Apr 24, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gabriela MazzantiA Loizzo
Mar 1, 1982·Clinical Pediatrics·D E Schuller, P J Oppenheimer
Aug 1, 1979·Quarterly Reviews of Biophysics·J Giesecke, H Hebert
Jan 1, 1984·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·V T Popa
Jan 1, 1984·The Journal of Pharmacy and Pharmacology·A P IjzermanJ Zaagsma
Nov 1, 1987·American Journal of Hematology·P J SpagnuoloS N Bass

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