PMID: 8942333Oct 1, 1996Paper

Potency and time course of action of rocuronium during desflurane and isoflurane anaesthesia

British Journal of Anaesthesia
N KumarG J McCarthy

Abstract

We have studied the potency and onset and duration of action of rocuronium in patients anaesthetized with 1 MAC of desflurane or isoflurane (in 66% nitrous oxide). Potency was estimated using the single bolus dose technique. Neuromuscular block was measured by stimulation of the ulnar nerve and recording the force of contraction of the adductor pollicis muscle. The ED50 and ED95 of rocuronium were estimated as 138 (95% confidence limits 117-162) micrograms kg-1 and 281 (241-328) micrograms kg-1, and 126 (105-151) micrograms kg-1 and 283 (236-339) micrograms kg-1 during desflurane and isoflurane anaesthesia, respectively. The mean times to onset of maximum block after rocuronium 0.6 mg kg-1 were 1.0 (SD 0.10) min and 1.1 (0.15) min, respectively, during anaesthesia with desflurane and isoflurane. The respective times to recovery of T1 (the first response in the train-of-four (TOF) stimulation) to 25% and 90% were 36 (8.3) min and 54 (15.4) min during desflurane anaesthesia and 31 (8.2) min and 45 (12.7) min during isoflurane anaesthesia. The times to recovery of the TOF ratio to 0.7 were 66 (13.4) min and 52 (16.3) min and the 25-75% recovery indices 14 (5.3) min and 10 (3.2) min, respectively, in the desflurane and isoflurane g...Continue Reading

Citations

Jul 21, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H WulfD Sitzlack
Jan 23, 2009·European Journal of Anaesthesiology·Harald IhmsenTino Muenster
Feb 1, 2005·European Journal of Anaesthesiology·P G MaidatsiM M Giala
Jan 11, 2001·Acta Anaesthesiologica Scandinavica·B Woloszczuk-GebickaW Wierzejski
Apr 11, 2017·Case Reports in Anesthesiology·Michael S GreenRanjani Venkataramani
Jan 7, 2000·Anesthesia and Analgesia·T Heier, J E Caldwell

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