PMID: 6025123Jun 23, 1967Paper

Potency difference between the zwitterion form and the cation forms of tetrodotoxin

Science
G CamougisJ R Tasse

Abstract

Tetrodotoxin can exist as a zwitterion or two different cations in aqueous solutions. The cation forms are more potent in nerve block. Thus the lactone-hemilactal configuration of tetrodotoxin influences potency. Electrostatic attraction, hydrogen bonding, and intermolecular hemilactal formation are possible mechanisms of interaction with membrane receptors.

References

Nov 1, 1964·Chemical & Pharmaceutical Bulletin·K TsudaK Sakai
Aug 1, 1965·Tetrahedron·T GotoY Hirata
Jan 1, 1952·Cold Spring Harbor Symposia on Quantitative Biology·R DE NO LORENTE

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Citations

Jan 1, 1969·Journal of Neurobiology·T NarahashiR N Poston
Nov 22, 1976·The Journal of Membrane Biology·J S D'Arrigo
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·S L Hu, C Y Kao
Feb 1, 1968·The Journal of General Physiology·B Hille
Feb 1, 1968·The Journal of General Physiology·B Hille
Apr 1, 1970·The Journal of General Physiology·R VillegasG Camejo
Apr 1, 1976·The Journal of Pharmacy and Pharmacology·A W Cuthbert
Dec 1, 1973·Experientia·E Zlotkin
Jul 1, 1981·Clinical Toxicology·D J BowerM E Howden
Jan 1, 1970·Progress in Biophysics and Molecular Biology·B Hille
Mar 12, 1968·Biochemical and Biophysical Research Communications·E W Hopkins, E J Herbst
Jul 1, 1979·Archives of Biochemistry and Biophysics·J K Reed, W Trzos
Jan 1, 1986·Annals of the New York Academy of Sciences·C Y Kao
Sep 1, 1986·Annals of Emergency Medicine·J K Sims, D C Ostman
Dec 25, 2012·Toxicon : Official Journal of the International Society on Toxinology·Edward G Moczydlowski

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