Potency of a novel saw palmetto ethanol extract, SPET-085, for inhibition of 5alpha-reductase II

Advances in Therapy
Pilar Pais

Abstract

The nicotinamide adenine dinucleotide phosphate (NADPH)-dependent membrane protein 5alpha-reductase irreversibly catalyses the conversion of testosterone to the most potent androgen, 5alpha-dihydrotestosterone (DHT). In humans, two 5alpha-reductase isoenyzmes are expressed: type I and type II. Type II is found primarily in prostate tissue. Saw palmetto extract (SPE) has been widely used for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH). The mechanisms of the pharmacological effects of SPE include the inhibition of 5alpha-reductase, among other actions. Clinical studies of SPE have been equivocal, with some showing significant results and others not. These inconsistent results may be due, in part, to varying bioactivities of the SPE used in the studies. The aim of the present study was to determine the in vitro potency of a novel saw palmetto ethanol extract (SPET-085), an inhibitor of the 5alpha-reductase isoenzyme type II, in a cell-free test system. On the basis of the enzymatic conversion of the substrate androstenedione to the 5alpha-reduced product 5alpha-androstanedione, the inhibitory potency was measured and compared to those of finasteride, an approved 5alpha-reductase in...Continue Reading

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Citations

Sep 29, 2011·JAMA : the Journal of the American Medical Association·Michael J BarryUNKNOWN Complementary and Alternative Medicine for Urological Symptoms (CAMUS) Study Group
Oct 5, 2011·Therapeutic Advances in Urology·Petrisor GeavleteBogdan Geavlete
Sep 27, 2013·Nutrients·Kavitha Penugonda, Brian L Lindshield
Sep 27, 2014·Journal of Ethnopharmacology·Daniel K AfriyieZhen-Feng Hong
May 31, 2014·Expert Opinion on Therapeutic Targets·Ruchy Jain, Wanchai De-Eknamkul
May 27, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruchy JainWanchai De-Eknamkul
May 15, 2013·Expert Opinion on Drug Discovery·Rajnish KumarManoj Kumar
Feb 18, 2017·Phytotherapy Research : PTR·Olubukola Oyebimpe AkanniOluwatosin Adekunle Adaramoye
Jul 21, 2017·Fundamental & Clinical Pharmacology·Ismail Ogunbayode IsholaVictoria U Udokwu
Aug 5, 2017·BMC Complementary and Alternative Medicine·Woo-Young JeonMee-Young Lee

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