Potency of monomethyl-, dimethylformamide and some of their metabolites to induce abnormal development in a limb Bud organ culture

Toxicology in Vitro : an International Journal Published in Association with BIBRA
S KlugR Jäckh

Abstract

DMF, NMF and their major metabolites were investigated for their developmental toxicity in the mouse limb bud assay. We found that neither DMF, NMF nor the predominant urinary metabolite HMFF exhibited developmental activity. In contrast, all metabolites resulting from the glutathione binding pathway, SMG, SMC and AMCC showed potent developmental activity. Under the chosen exposure conditions, the developmental toxicity of DMF in different species appears to be related to the magnitude of glutathione binding. The results further show the value of using an in vitro system which is incapable of metabolic transformation of exogenous compounds for the identification of ultimate teratogenic species.

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Citations

Apr 15, 2004·Reproductive Toxicology·Karen A Augustine-RauchMichael J Welsh
Sep 28, 2012·Critical Reviews in Toxicology·Gerald L Kennedy
Aug 31, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Holly ZhouCheryl M Coffin

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