Potent and Persistent Antibody Response in COVID-19 Recovered Patients.

Frontiers in Immunology
Xiaodong TianJing Li

Abstract

SARS-CoV-2 has caused a global pandemic with millions infected and numerous fatalities. Virus-specific antibodies can be detected in infected patients approximately two weeks after symptom onset. In this study, we set up ELISA technology coating with purified SARS-CoV-2 S and N proteins to study the antibody response of 484 serum samples. We established a surrogate viral inhibition assay using SARS-CoV-2 S protein pseudovirus system to determine the neutralization potency of collected serum samples. Here, we report robust antibody responses to SARS-CoV-2 in 484 recovered patients varying from 154 to 193 days, with 92% of recovered patients displaying a positive virus-specific spike glycoprotein IgG (s-IgG) response, while the ratio of positive spike glycoprotein IgM (s-IgM) reached 63%. Furthermore, moderate to potent neutralization activities were also observed in 62% of patients, correlating significantly with s-IgG response. This study strongly supports the long-term presence of antibodies in recovered patients against SARS-CoV-2, although all serum samples were collected from individuals with mild or moderate symptoms.

References

Jan 23, 1999·Journal of Immunological Methods·A FreyD Zurakowski
Feb 23, 2020·The Lancet Infectious Diseases·Xingfei PanJing Liu
Apr 23, 2020·Nature Reviews. Immunology·Akiko Iwasaki, Yexin Yang
Apr 30, 2020·Nature Reviews. Immunology·Verena van der Heide
May 1, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
May 16, 2020·Cell Host & Microbe·Yanling WuTianlei Ying
Jun 20, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
Jul 8, 2020·The Journal of Clinical Investigation·Yanqun WangJincun Zhao
Sep 2, 2020·The New England Journal of Medicine·Daniel F GudbjartssonKari Stefansson
Oct 30, 2020·Science·Ania WajnbergCarlos Cordon-Cardo
Nov 12, 2020·BioRxiv : the Preprint Server for Biology·Christian GaeblerRoshni Patel
Jan 15, 2021·BioRxiv : the Preprint Server for Biology·Jennifer M DanShane Crotty

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