Potent and selective proline derived dipeptidyl peptidase IV inhibitors

Bioorganic & Medicinal Chemistry Letters
Scott D EdmondsonEmma R Parmee

Abstract

In-house screening of the Merck sample collection identified proline derived homophenylalanine 3 as a DPP-IV inhibitor with modest potency (DPP-IV IC50=1.9 microM). Optimization of 3 led to compound 37, which is among the most potent and selective DPP-IV inhibitors discovered to date.

References

Jan 9, 2003·Expert Opinion on Investigational Drugs·Daniel J Drucker

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Citations

Aug 7, 2007·Journal of Molecular Modeling·Raghuvir R S PissurlenkarEvans C Coutinho
Oct 13, 2009·Journal of Combinatorial Chemistry·Sujata RoyRichard C Larock
Oct 9, 2013·Journal of Medicinal Chemistry·Lucienne Juillerat-Jeanneret
Dec 1, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J ShangM G Beconi
Feb 18, 2014·European Journal of Medicinal Chemistry·Bhumika D Patel, Manjunath D Ghate
May 4, 2017·Medicinal Research Reviews·Subha Kalyaanamoorthy, Khaled H Barakat
Mar 6, 2007·Bioorganic & Medicinal Chemistry Letters·Gregory C AdamKevin T Chapman
Aug 9, 2005·Bioorganic & Medicinal Chemistry Letters·Kevin R ShrederJohn W Kozarich
Jun 6, 2008·Bioorganic & Medicinal Chemistry Letters·Gui-Bai LiangAnn E Weber
Feb 10, 2009·Chembiochem : a European Journal of Chemical Biology·Teresa SardonIsabelle Vernos
Jun 24, 2008·Journal of Medicinal Chemistry·William K Hagmann
Apr 17, 2007·Bioorganic & Medicinal Chemistry Letters·Dooseop KimAnn E Weber
Feb 17, 2009·Bioorganic & Medicinal Chemistry·Shrikanth H Havale, Manojit Pal

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