Potent antibody therapeutics by design

Nature Reviews. Immunology
Paul J Carter

Abstract

Antibodies constitute the most rapidly growing class of human therapeutics and the second largest class of drugs after vaccines. The generation of potent antibody therapeutics, which I review here, is an iterative design process that involves the generation and optimization of antibodies to improve their clinical potential.

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P CarterH M Shepard
Dec 5, 1991·Journal of Molecular Biology·J D MarksG Winter
Sep 18, 1990·Biochemistry·J A Wells
Mar 25, 1988·Science·M VerhoeyenG Winter
Mar 24, 1988·Nature·L RiechmannG Winter
Apr 21, 1988·Nature·A R Duncan, G Winter
Dec 13, 1984·Nature·G L BoulianneM J Shulman
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S L MorrisonV T Oi
Jun 1, 1994·The Journal of Clinical Investigation·K J ParlevlietP T Schellekens
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·J S BabcookJ W Schrader
Sep 1, 1996·Journal of Transplant Coordination : Official Publication of the North American Transplant Coordinators Organization (NATCO)·S L Smith
Jul 1, 1997·Nature Biotechnology·P HolligerG Winter
Jul 1, 1997·Nature Biotechnology·V GhetieE S Ward
Sep 10, 1998·Oncology·C KosmasA A Epenetos
Aug 3, 1999·Nature Biotechnology·A P ChapmanD J King
Nov 7, 1999·Cancer Immunology, Immunotherapy : CII·A R AmorosoL M Weiner
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E E IdusogieM G Mulkerrin
Aug 1, 2000·Immunology Today·M J Glennie, P W Johnson
Sep 1, 2000·Journal of Molecular Biology·M A PoulJ D Marks
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T KelerR F Graziano
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E E IdusogieM G Mulkerrin
Apr 5, 2001·Current Opinion in Biotechnology·H E Chadd, S M Chamow

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Citations

Mar 1, 2012·Analytical and Bioanalytical Chemistry·Kaiguang YangYukui Zhang
Sep 19, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Lars R PerkGuus A M S van Dongen
Apr 21, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Stefanie PfaffenDario Neri
Jul 28, 2007·Cancer Immunology, Immunotherapy : CII·Sophia N KaragiannisHannah J Gould
Mar 5, 2008·Cancer Immunology, Immunotherapy : CII·Karl-Johan MalmbergHans-Gustaf Ljunggren
Aug 7, 2009·Cancer Immunology, Immunotherapy : CII·Pina M CardarelliDavid J King
Nov 11, 2006·Springer Seminars in Immunopathology·Lydie CassardCatherine Sautès-Fridman
Aug 25, 2009·Bioprocess and Biosystems Engineering·In-Seok OhDong-Myung Kim
Feb 5, 2010·Biotechnology Letters·A ConstantinouM P Deonarain
Feb 14, 2009·Cellular and Molecular Neurobiology·Eva KontsekovaMichal Novak
Mar 13, 2010·Clinical & Experimental Metastasis·Karin StaflinBrunhilde Felding-Habermann
Nov 13, 2008·Cytotechnology·Makiko YamashitaSanetaka Shirahata
Mar 31, 2011·Pharmaceutical Research·Paolo ArosioMassimo Morbidelli
Mar 20, 2012·Molecular Biotechnology·Dmitrij HristodorovLars Linden
Oct 26, 2012·Molecular Biotechnology·Dmitrij HristodorovLars Linden
Oct 14, 2011·International Journal of Hematology·Takashi Ishida, Ryuzo Ueda
Apr 12, 2013·Virologica Sinica·Zhongyu ZhuDimiter S Dimitrov
Jan 19, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Philippe Fournier, Volker Schirrmacher
Jan 10, 2013·Clinical Pharmacokinetics·Miroslav DostalekManoranjenni Chetty
May 8, 2013·Developmental and Comparative Immunology·B AlvarezC Revilla
Aug 24, 2012·Analytical Chemistry·Lan N LeWilliam J Galush
Jan 29, 2013·Bioconjugate Chemistry·Martina SteinerDario Neri
Nov 17, 2010·Journal of the American Chemical Society·Qing LiCarston R Wagner
Aug 10, 2010·Acta Pharmacologica Sinica·Jing Li, Zhenping Zhu
Feb 6, 2013·Acta Pharmacologica Sinica·Han Sun, Min Li
Mar 10, 2010·Immunology and Cell Biology·Xuekai ZhuBin Gao
Sep 22, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Meng LiDexian Zheng
May 8, 2007·Nature Biotechnology·Sachdev S Sidhu
Sep 10, 2008·Nature Biotechnology·Christian K Schneider, Ulrich Kalinke
Dec 11, 2007·Nature Biotechnology·Jochen G Salfeld
Dec 11, 2007·Nature Biotechnology·Wayne A Marasco, Jianhua Sui

❮ Previous
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