Potent anticancer efficacy of first-in-class Cu(II) and Au(III) metaled phosphorus dendrons with distinct cell death pathways

Chemistry : a European Journal
J P MajoralXiangyang Shi

Abstract

First-in-class Cu(II) and Au(III) metaled phosphorus dendrons were synthesized and showed significant antiproliferative activity against several aggressive breast cancer cell lines. The data suggest that the cytotoxicity increases with reducing the length of the alkyl chains, whereas the replacement of Cu(II) by Au(III) considerably increases the antiproliferative activity of metaled phosphorus dendrons. Very interestingly, we found that the cell death pathway is related to the nature of the metal complexed by the plain dendrons. Cu(II) metaled dendrons showed a potent caspase-independent cell death pathway; whereas Au(III) metaled dendrons displayed a caspase-dependent apoptotic pathway. The complexation of plain dendrons with Au(III) increased the cellular lethality versus dendrons with Cu(II) and promoted the translocation of Bax into the mitochondria and the release of Cytochrome C (Cyto C).

References

Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·J M RobertsJ Massagué
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·J M JürgensmeierJ C Reed
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NaritaY Tsujimoto
Apr 14, 1999·Cell Death and Differentiation·A G Porter, R U Jänicke
Dec 13, 2001·Chemical Reviews·S M Grayson, J M Fréchet
Mar 2, 2005·Nature Reviews. Cancer·Mauro Ferrari
Aug 23, 2005·Molecular Aspects of Medicine·Miguel Arredondo, Marco T Núñez
Oct 14, 2005·Journal of Medicinal Chemistry·Marcella CoronnelloLuigi Messori
Jun 21, 2006·Biochimica Et Biophysica Acta·Kuppusamy Balamurugan, Walter Schaffner
Jan 8, 2008·Journal of Inorganic Biochemistry·Angela CasiniLuigi Messori
Jan 6, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Denis B Buxton
Mar 27, 2010·Current Pharmaceutical Design·Michael FrezzaQ Ping Dou
Feb 1, 2011·Antioxidants & Redox Signaling·Ute JungwirthPetra Heffeter
Apr 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yechezkel Barenholz
Jan 1, 2010·Cancers·Therese Christina Karlenius, Kathryn Fay Tonissen
Apr 4, 2014·Journal of the American Chemical Society·Kate J AkermanOrde Q Munro
May 31, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Charlene M DawidczykPeter C Searson
Mar 30, 2017·European Journal of Medicinal Chemistry·Serge MignaniThierry Cresteil
Apr 21, 2017·Drug Design, Development and Therapy·Umar NdagiMahmoud E Soliman

❮ Previous
Next ❯

Citations

Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anne-Marie Caminade
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Serge MignaniJean-Pierre Majoral
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Artem ZibarovAnne-Marie Caminade

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.