Potent Antiviral Activities of Type I Interferons to SARS-CoV-2 Infection.

BioRxiv : the Preprint Server for Biology
E. K. MantloCheng Huang

Abstract

The historical outbreak of COVID-19 disease not only constitutes a global public health crisis, but also has a devastating social and economic impact. The disease is caused by a newly identified coronavirus, Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). There is an urgent need to identify antivirals to curtail the COVID-19 pandemic. Herein, we report the remarkable sensitivity of SARS-CoV-2 to recombinant human interferons α and β (IFNα/β). Treatment with IFN-α or IFN-β at a concentration of 50 international units (IU) per milliliter drastically reduce viral titers by 3.4 log or 4.5 log, respectively in Vero cells. The EC50 of IFN-α and IFN-β treatment is 1.35 IU/ml and 0.76 IU/ml, respectively, in Vero cells. These results suggested that SARS-CoV-2 is more sensitive to many other human pathogenic viruses, including the SARS-CoV. Overall, our results demonstrate the potent efficacy of human Type I IFN in suppressing SARS-CoV-2 replication, a finding which could inform future treatment options for COVID-19.

Citations

Aug 9, 2020·Frontiers in Cell and Developmental Biology·Ligong LuYou-Wen He
Sep 25, 2020·Journal of Translational Medicine·Francesca CaccuriArnaldo Caruso
Aug 1, 2020·Nature Communications·Xiaobo LeiJianwei Wang
Jun 27, 2020·The Journal of Biological Chemistry·Ulrike FelgenhauerFriedemann Weber
Oct 6, 2020·Viral Immunology·Areej M AssafAmal A Akour
Sep 15, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Anupama M Gudadappanavar, Jyoti Benni
Apr 30, 2021·Frontiers in Immunology·Jintao ZhangWei Zhao

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