Potent cholecystokinin antagonist L 364718 stimulates food intake in rats.

The American Journal of Physiology
R D Reidelberger, M F O'Rourke

Abstract

The cholecystokinin (CCK) receptor antagonist L 364718 was used to examine the role of CCK in control of food intake. Effects of L 364718 (0.01-1 mg/kg ip) on the feeding response to a maximal inhibitory dose of cholecystokinin COOH-terminal octapeptide (CCK-8; 8 nmol/kg ip) and on food intake alone were determined in rats fed ad libitum during the dark cycle. CCK-8 suppressed feeding by 48%. L 364718 reversed this effect dose dependently; the minimal effective dose was 0.03 mg/kg, and complete reversal occurred at 0.1 and 0.3 mg/kg. L 364718 (0.03 mg/kg) caused a parallel, rightward shift in the dose-response curve to CCK-8 [1-128 nmol/kg, half-maximal effective dose (ED50) increased 16-fold] but did not alter the maximal response, consistent with competitive-like kinetics. L 364718 stimulated liquid and solid food intake dose-dependently by 11-35%. The minimal effective dose was 0.1 mg/kg; maximal stimulation occurred at 0.3 mg/kg. Duodenal infusion of bile-pancreatic juice did not alter the response. These results support an important role for CCK in control of food intake.

Citations

Nov 5, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerMartin Hulce
May 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerMartin Hulce
Apr 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sheng BiTimothy H Moran
Oct 18, 2012·American Journal of Physiology. Endocrinology and Metabolism·Stephen C Woods, Wolfgang Langhans
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L KellyH R Berthoud
Jan 1, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerMartin Hulce
Aug 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S BlumbergA Weller
May 15, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert C Ritter
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A Shemyakin, L Kapás
Nov 2, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James E BlevinsKozo Matsumoto
Dec 11, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephen C Woods
Feb 7, 2001·Annual Review of Psychology·S C WoodsR J Seeley
Jun 20, 1998·Science·S C WoodsM W Schwartz

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