PMID: 8585769Oct 1, 1995Paper

Potent inhibition of human immunodeficiency virus by MDL 101028, a novel sulphonic acid polymer

Antiviral Research
D L TaylorA D Cardin

Abstract

MDL 101028, a novel biphenyl disulphonic acid urea co-polymer was designed and synthesised as a heparin mimetic. This low molecular weight polymer showed potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication in a number of host-cell/virus systems, including primary clinical isolates of the virus cultured in human peripheral blood mononuclear cells (PBMCs). When compared with the heterogeneous polysulphated molecules, heparin and dextran sulphate, this chemically defined compound showed equivalent antiviral activity with 50% inhibitory concentrations (IC50s) in the range 0.27-3.0 micrograms/ml in the host-cell/virus systems tested. MDL 101028 also inhibited the replication of HIV type 2 and the simian immunodeficiency virus (SIV), as well as HIV-1 variants resistant to reverse transcriptase inhibitors. Virus growth was blocked when exposure of T-lymphocytes to MDL 101028 was restricted to the virus absorption stage, or even in whole blood conditions. MDL 101028 did not irreversibly inactivate virions, and in contrast to heparin, did not inhibit the attachment of radiolabelled HIV-1 to CD4+ T-cells. MDL 101028 blocked HIV-induced cell-to-cell fusion and this activity appears to explain the mechanism of its ...Continue Reading

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Citations

Apr 1, 1999·Biotechnology and Bioengineering·R O'KeeffeN K Slater
Apr 1, 1999·Biotechnology and Bioengineering·R S O'KeeffeN K Slater
Feb 2, 2010·Expert Reviews in Molecular Medicine·Allison H Bartlett, Pyong Woo Park
Nov 27, 2002·Antiviral Chemistry & Chemotherapy·Donald E BergstromErik De Clercq
Jun 28, 2017·Organic & Biomolecular Chemistry·Ryan J WeissYitzhak Tor
Nov 13, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chiara UrbinatiMarco Rusnati
Aug 6, 2020·Polymers·Natanel JarachSamuel Kenig

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