Potent inhibition of human ovarian steroidogenesis by insulin-like growth factor binding protein-4 (IGFBP-4)

The Journal of Clinical Endocrinology and Metabolism
H D MasonS Franks

Abstract

Several studies have now documented the existence of IGFBPs in follicular fluid and their correlation with the health of the follicle. In particular, increased levels of IGFBP-4 have been reported in androgen-dominant atretic follicles and those from polycystic ovaries. The aim of this study was to elucidate the role of IGFBP-4 in ovarian steroidogenesis. Granulosa cells and theca tissue were incubated with or without LH or FSH in the presence or absence of IGFBP-4 (0.5-50 ng/ml). Inhibition by IGFBP-4 of estradiol production in the presence of testosterone alone was seen in three of four experiments. IGFBP-4 completely inhibited FSH-stimulated estradiol production in three experiments and caused 67% inhibition in a fourth. Similar results were obtained for theca, in which concurrent incubation with IGFBP-4 completely negated the stimulatory effects of LH on androstenedione production. The mechanism by which IGFBP-4 exerts these potent effects and the possibility that this may by IGF-independent are currently being investigated.

Citations

Jul 19, 2005·Journal of Assisted Reproduction and Genetics·Dorothea M WunderNick A Bersinger
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·E Diamanti-Kandarakis, A Bergiele
Oct 21, 1999·Molecular Genetics and Metabolism·L A WetterauP Cohen
Apr 3, 2008·The Journal of Clinical Endocrinology and Metabolism·Claus Yding AndersenAnne Grete Byskov
Aug 24, 1999·Endocrine Reviews·L PoretskyL C Giudice
Nov 10, 2011·Human Reproduction Update·Angela R BaerwaldRoger A Pierson

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