Potent inhibitory effect of silibinin from milk thistle on skin inflammation stimuli by 12-O-tetradecanoylphorbol-13-acetate

Food & Function
Wenfeng LiuZhiyun Du

Abstract

Silibinin, a major polyphenol in milk thistle, has been reported to have multiple pharmacological activities; therefore, there is an urgent need to well understand how silibinin works on inflammation-associated skin diseases. We herein designed silibinin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated skin inflammation to test its inhibitory effects. It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1β (IL-1β), interleukin-6 (IL-6), necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2) in a dose-dependent manner. Further mechanistic investigations indicated that silibinin suppressed the expression of IκB kinase (IKK) by inhibiting the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, and thereby suppressing TPA-stimulated nuclear factor-κB (NF-κB) activation. Promisingly, silibinin, used for transdermal application, may be a potent naturally occurring anti-inflammatory agent for the prevention of inflammation-associated skin diseases.

References

Oct 20, 1995·The Journal of Biological Chemistry·S Singh, B B Aggarwal
Mar 15, 1997·Genes & Development·S G KennedyN Hay
Feb 19, 1998·The American Journal of Gastroenterology·K FloraK Benner
May 15, 1998·Journal of Ethnopharmacology·A H Atta, A Alkofahi
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Jul 12, 2002·Microscopy Research and Technique·Wolf D Splettstoesser, Peter Schuff-Werner
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Apr 19, 2006·Cancer Research·Nengtai OuyangBasil Rigas
Jun 6, 2007·Integrative Cancer Therapies·Janice Post-WhiteKara M Kelly
Jun 26, 2007·Molecular and Cellular Endocrinology·Anna Kleiman, Jan P Tuckermann
Apr 18, 2009·Respiratory Medicine·Stephanie C MansonCarlos Fernandez Vidaurre
Aug 6, 2009·BMC Complementary and Alternative Medicine·Tamsyn S A ThringDeclan P Naughton
Oct 1, 2004·Comprehensive Reviews in Food Science and Food Safety·M-T HuangC-T Ho

❮ Previous
Next ❯

Citations

Jan 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jana JuráňováJana Franková
Jun 27, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Cristina RigonLetícia Cruz
Jun 23, 2019·European Journal of Pharmacology·Kanyasiri RakariyathamHang Xiao
May 7, 2019·Autoimmunity Reviews·Haroon KhanMichael Aschner

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here