Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1alpha,25-dihydroxyvitamin D3

The Journal of Steroid Biochemistry and Molecular Biology
Gary H PosnerSamuel S Chuang

Abstract

The new 24-phenylsulfone 4a, a low-calcemic analog of the natural hormone 1alpha,25-dihydroxyvitamin D(3), is a potent (IC(50) = 28nM) and highly selective inhibitor of the human 24-hydroxylase enzyme CYP24.

References

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Citations

Mar 10, 2010·Biochemistry. Biokhimii︠a︡·L A NovikovaV M Shkumatov
Jul 14, 2010·Biochimica Et Biophysica Acta·Inge Schuster
Apr 29, 2015·Canadian Journal of Physiology and Pharmacology·Yotaro MatsumotoTai C Chen
Jun 1, 2010·Endocrinology and Metabolism Clinics of North America·Glenville Jones
Jul 26, 2005·Bioorganic & Medicinal Chemistry·Gary H PosnerThomas W Kensler
Feb 3, 2006·Natural Product Reports·James R Hanson
Mar 17, 2005·British Journal of Cancer·M J Larriba, A Muñoz
Aug 28, 2007·Nature Reviews. Cancer·Kristin K DeebCandace S Johnson
Jun 27, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Manraj Johal, Adeera Levin
Apr 6, 2007·Journal of Neural Engineering·Ali BashashatiGary E Birch
Aug 13, 2013·Angewandte Chemie·Ulrich Lücking
May 2, 2006·Molecular Cancer Therapeutics·Sonoko Masuda, Glenville Jones
Jun 5, 2007·Bioorganic & Medicinal Chemistry·Robert D Bruno, Vincent C O Njar
May 7, 2014·ACS Medicinal Chemistry Letters·Preetpal S SidhuLeggy A Arnold

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