Potent PBS/Polysorbate-Soluble Transplatin-Derived Porphyrin-Based Photosensitizers for Photodynamic Therapy.

Inorganic Chemistry
Lukas SchneiderBernhard Spingler

Abstract

In this study, we addressed an important drawback of our previously reported tetraplatinated (metallo)porphyrin-based photosensitizers (PSs) for photodynamic therapy (PDT), namely, the poor solubility in aqueous media. We aimed to create tetraplatinated porphyrin-based PSs that are soluble in aqueous media modified with polysorbate (Tween) and do not need to be pre-dissolved in organic solvents. A structural optimization of the previously reported PSs resulted in the synthesis of an extremely potent novel porphyrin-based PS. The novel PS displays effective phototoxicity upon light irradiation against multicellular tumor spheroids and has a phototoxic index (PI) of 6030 in HeLa cells. This PI value is, to the best of our knowledge, the highest value reported for any porphyrin so far.

References

Apr 26, 2007·Chemical Reviews·Yongwon Jung, Stephen J Lippard
Sep 24, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Frédéric SchmittBruno Therrien
Feb 28, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Christiane PavaniMaurício S Baptista
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
May 24, 2014·Angewandte Chemie·Anu NaikBernhard Spingler
Nov 26, 2014·Chemistry : a European Journal·Philipp M AntoniBernhard Spingler
Apr 2, 2016·International Journal of Oncology·Bianca GalateanuOctav Ginghina
Aug 9, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Thiago T TassoBernardo A Iglesias
May 3, 2018·Acta Pharmaceutica Sinica. B·Juan ZhangLuis Alexandre Muehlmann
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Stanisław KwiatkowskiJulita Kulbacka
May 7, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xutong ShiZhenjia Wang
May 9, 2019·Advanced Healthcare Materials·Minhuan LanPengfei Wang
Jun 4, 2019·Photodermatology, Photoimmunology & Photomedicine·Rebecca L YanovskySteven T Chen
Oct 19, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Lukas SchneiderBernhard Spingler
Dec 4, 2019·Journal of Photochemistry and Photobiology. B, Biology·Gabriela Klein CoutoTiago Collares
Jun 28, 2020·Nature Communications·Johannes KargesGilles Gasser
Nov 4, 2020·Chemical Communications : Chem Comm·Riccardo RubbianiBernhard Spingler
May 15, 2021·Journal of Medicinal Chemistry·Ngoc An LeBernhard Spingler

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