Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice.

PloS One
Young-il KimTeruo Kawada

Abstract

Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10,12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo-ODA, we developed that 13-oxo-9,11-octadecadienoic acid (13-oxo-ODA), which is an isomer of 9-oxo-ODA, is present only in tomato juice. In this study, we explored the possibility that 13-oxo-ODA acts as a PPARα agonist in vitro and whether its effect ameliorates dyslipidemia and hepatic steatosis in vivo. In vitro luciferase assay experiments revealed that 13-oxo-ODA significantly induced PPARα activation; moreover, the luciferase activity of 13-oxo-ODA was stronger than that of 9-oxo-ODA and conjugated linoleic acid (CLA), which is a precursor of 13-oxo-ODA and is well-known as a potent PPARα activator. In addition to in vitro experiment, treatment with 13-oxo-ODA decreased the levels of plasma and hepatic triglycerides in obese KK-Ay mice fed a high-fat diet. In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARα agonist, suggesti...Continue Reading

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Citations

Aug 3, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Feten Zar KalaiHiroko Isoda
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shigenobu KishinoJun Ogawa
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Nov 28, 2012·Molecular Nutrition & Food Research·Tsuyoshi GotoTeruo Kawada
Mar 2, 2016·Journal of Agricultural and Food Chemistry·Futoshi NakamuraShigeru Fujiwara
Jul 26, 2014·Bioscience, Biotechnology, and Biochemistry·Haruya TakahashiTeruo Kawada
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Oct 18, 2013·Journal of Lipid Research·Rino KimuraTeruo Kawada
Jan 27, 2018·Bioscience, Biotechnology, and Biochemistry·Teruo Kawada
Apr 15, 2016·PloS One·Cassiano Felippe Gonçalves-de-AlbuquerqueHugo Caire de Castro-Faria-Neto
Feb 10, 2020·Digestive Diseases and Sciences·Samaa Shama, Wanqing Liu
Oct 2, 2020·The Journal of Sports Medicine and Physical Fitness·Masayuki TanakaHidemi Fujino
Dec 10, 2016·Journal of Agricultural and Food Chemistry·Haruya TakahashiTeruo Kawada

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Methods Mentioned

BETA
transfection
dissection
ELISA
PCR

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