Potent therapeutic activity of folate receptor-targeted liposomal carboplatin in the localized treatment of intraperitoneally grown human ovarian tumor xenograft.

International Journal of Nanomedicine
Anumita ChaudhuryGigi N C Chiu

Abstract

Intraperitoneal (IP) therapy with platinum (Pt)-based drugs has shown promising results clinically; however, high locoregional concentration of the drug could lead to adverse side effects. In this study, IP administration was coupled with a folate receptor-targeted (FRT) liposomal system, in an attempt to achieve intracellular delivery of the Pt-based drug carboplatin in order to increase therapeutic efficacy and to minimize toxicity. In vitro and in vivo activity of FRT carboplatin liposomes was compared with the activity of free drug and nontargeted (NT) carboplatin liposomes using FR-overexpressing IGROV-1 ovarian cancer cells as the model. Significant reduction in cell viability was observed with FRT liposomes, which, compared with the free drug, provided an approximately twofold increase in carboplatin potency. The increase in drug potency was correlated with significantly higher cellular accumulation of Pt resulting from FRT liposomal delivery. Further evaluation was conducted in mice bearing intraperitoneally inoculated IGROV-1 ovarian tumor xenografts. A superior survival rate (five out of six animals) was achieved in animals treated with FRT carboplatin liposomes, injected intraperitoneally with a dose of 15 mg/kg and ...Continue Reading

References

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Citations

Apr 15, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Terrick AndeyMandip Singh
Nov 24, 2012·Biomaterials·Julie TomasinaAurélie Malzert-Fréon
Feb 12, 2013·Current Opinion in Chemical Biology·Jennifer S Butler, Peter J Sadler
Dec 24, 2014·Gynécologie, obstétrique & fertilité·F GrecoJ Perrin

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Methods Mentioned

BETA
xenograft
atomic absorption spectroscopy
transmission electron microscopy
blood collection

Software Mentioned

GraphPad Prism
GraphPad
MedCalc
CalcuSyn

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